# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4767282 | B | Metal chelating activity assessed as copper chelation by UV-Visible spectrophotometry | 2 | assay format | Scientific Literature | |||
2. | ALA4767291 | F | Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 48 hrs by cell-titer-Glo luminescent cell viability assay | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
3. | ALA4767292 | A | Cytotoxicity against HUVEC assessed as reduction in cell viability incubated for 48 hrs by cell-titer-Glo luminescent cell viability assay | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
4. | ALA4767293 | T | Selectivity index, ratio of IC50 for HUVEC to IC50 for human MV4-11 cells | 18 | assay format | Scientific Literature | |||
5. | ALA4767294 | A | Half life in mouse liver microsomes at 10 uM preincubated for 5 mins followed by NADPH addition and measured up to 45 mins by LC/MS analysis | Mus musculus | 6 | microsome format | Scientific Literature | ||
6. | ALA4767295 | A | Intrinsic clearance mouse in liver microsomes at 10 uM preincubated for 5 mins followed by NADPH addition and measured up to 45 mins by LC/MS analysis | Mus musculus | 6 | subcellular format | Scientific Literature | ||
7. | ALA4767296 | A | Half life in mouse at 1 mg/kg, iv | Mus musculus | 1 | organism-based format | Scientific Literature | ||
8. | ALA4767297 | A | Clearance in mouse at 1 mg/kg, iv | Mus musculus | 1 | organism-based format | Scientific Literature | ||
9. | ALA4767298 | A | AUClast in mouse at 1 mg/kg, iv | Mus musculus | 1 | organism-based format | Scientific Literature | ||
10. | ALA4767299 | A | Half life in mouse at 10 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
11. | ALA4767300 | A | Cmax in mouse at 10 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
12. | ALA4767301 | A | AUClast in mouse at 10 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
13. | ALA4767302 | A | Oral bioavailability in mouse at 10 mg/kg | Mus musculus | 1 | organism-based format | Scientific Literature | ||
14. | ALA4767303 | F | Antitumor activity against human MV4-11 cells xenografted in BALB/c nude mouse assessed as tumor growth inhibition at 30 mg/kg, po BID administered via gavage by caliper method | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
15. | ALA4767304 | T | Toxicity in BALB/c nude mouse xenografted with human MV4-11 cells assessed as effect on body weight at 30 mg/kg, po BID administered via gavage for 14 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
16. | ALA4767305 | F | Induction of cell cycle arrest in human MV4-11 cells assessed as accumulation at G1 phase at 50 nM measured after 24 hrs by propidium iodide staining based FACScalibur flow cytometry analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
17. | ALA4767306 | F | Induction of cell death in human MV4-11 cells at 50 nM measured after 48 hrs by propidium iodide staining based FACScalibur flow cytometry analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
18. | ALA4767307 | F | Induction of cell death in human MV4-11 cells assessed as reduction in cell viability at 50 nM measured after 48 hrs in presence of Z-VAD by cell-titer-Glo luminescent cell viability assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
19. | ALA4767308 | F | Induction of cell death in human MV4-11 cells assessed as reduction in cell viability at 50 nM measured after 48 hrs in presence of Nec-1 by cell-titer-Glo luminescent cell viability assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
20. | ALA4767309 | F | Induction of cell death in human MV4-11 cells assessed as reduction in cell viability at 50 nM measured after 48 hrs in presence of Nec-1 and Z-VAD by cell-titer-Glo luminescent cell viability assay | Homo sapiens | 1 | cell-based format | Scientific Literature |