| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4767282 | B | Metal chelating activity assessed as copper chelation by UV-Visible spectrophotometry | 2 | ALA4765242 | assay format | Scientific Literature | ||
| 2. | ALA4767291 | F | Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 48 hrs by cell-titer-Glo luminescent cell viability assay | Homo sapiens | 18 | ALA4765242 | cell-based format | Scientific Literature | |
| 3. | ALA4767292 | A | Cytotoxicity against HUVEC assessed as reduction in cell viability incubated for 48 hrs by cell-titer-Glo luminescent cell viability assay | Homo sapiens | 18 | ALA4765242 | cell-based format | Scientific Literature | |
| 4. | ALA4767293 | T | Selectivity index, ratio of IC50 for HUVEC to IC50 for human MV4-11 cells | 18 | ALA4765242 | assay format | Scientific Literature | ||
| 5. | ALA4767294 | A | Half life in mouse liver microsomes at 10 uM preincubated for 5 mins followed by NADPH addition and measured up to 45 mins by LC/MS analysis | Mus musculus | 6 | ALA4765242 | microsome format | Scientific Literature | |
| 6. | ALA4767295 | A | Intrinsic clearance mouse in liver microsomes at 10 uM preincubated for 5 mins followed by NADPH addition and measured up to 45 mins by LC/MS analysis | Mus musculus | 6 | ALA4765242 | subcellular format | Scientific Literature | |
| 7. | ALA4767296 | A | Half life in mouse at 1 mg/kg, iv | Mus musculus | 1 | ALA4765242 | organism-based format | Scientific Literature | |
| 8. | ALA4767297 | A | Clearance in mouse at 1 mg/kg, iv | Mus musculus | 1 | ALA4765242 | organism-based format | Scientific Literature | |
| 9. | ALA4767298 | A | AUClast in mouse at 1 mg/kg, iv | Mus musculus | 1 | ALA4765242 | organism-based format | Scientific Literature | |
| 10. | ALA4767299 | A | Half life in mouse at 10 mg/kg, po | Mus musculus | 1 | ALA4765242 | organism-based format | Scientific Literature | |
| 11. | ALA4767300 | A | Cmax in mouse at 10 mg/kg, po | Mus musculus | 1 | ALA4765242 | organism-based format | Scientific Literature | |
| 12. | ALA4767301 | A | AUClast in mouse at 10 mg/kg, po | Mus musculus | 1 | ALA4765242 | organism-based format | Scientific Literature | |
| 13. | ALA4767302 | A | Oral bioavailability in mouse at 10 mg/kg | Mus musculus | 1 | ALA4765242 | organism-based format | Scientific Literature | |
| 14. | ALA4767303 | F | Antitumor activity against human MV4-11 cells xenografted in BALB/c nude mouse assessed as tumor growth inhibition at 30 mg/kg, po BID administered via gavage by caliper method | Homo sapiens | 1 | ALA4765242 | organism-based format | Scientific Literature | |
| 15. | ALA4767304 | T | Toxicity in BALB/c nude mouse xenografted with human MV4-11 cells assessed as effect on body weight at 30 mg/kg, po BID administered via gavage for 14 days | Mus musculus | 1 | ALA4765242 | organism-based format | Scientific Literature | |
| 16. | ALA4767305 | F | Induction of cell cycle arrest in human MV4-11 cells assessed as accumulation at G1 phase at 50 nM measured after 24 hrs by propidium iodide staining based FACScalibur flow cytometry analysis | Homo sapiens | 1 | ALA4765242 | cell-based format | Scientific Literature | |
| 17. | ALA4767306 | F | Induction of cell death in human MV4-11 cells at 50 nM measured after 48 hrs by propidium iodide staining based FACScalibur flow cytometry analysis | Homo sapiens | 1 | ALA4765242 | cell-based format | Scientific Literature | |
| 18. | ALA4767307 | F | Induction of cell death in human MV4-11 cells assessed as reduction in cell viability at 50 nM measured after 48 hrs in presence of Z-VAD by cell-titer-Glo luminescent cell viability assay | Homo sapiens | 1 | ALA4765242 | cell-based format | Scientific Literature | |
| 19. | ALA4767308 | F | Induction of cell death in human MV4-11 cells assessed as reduction in cell viability at 50 nM measured after 48 hrs in presence of Nec-1 by cell-titer-Glo luminescent cell viability assay | Homo sapiens | 1 | ALA4765242 | cell-based format | Scientific Literature | |
| 20. | ALA4767309 | F | Induction of cell death in human MV4-11 cells assessed as reduction in cell viability at 50 nM measured after 48 hrs in presence of Nec-1 and Z-VAD by cell-titer-Glo luminescent cell viability assay | Homo sapiens | 1 | ALA4765242 | cell-based format | Scientific Literature |
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