#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4689777	Binding	Displacement of [3H]-PGE2 from human EP3 expressed in Chem-1 cell membranes incubated for 2 hrs by TopCount scintillation plate reader analysis	Homo sapiens	48	ALA4680377	cell membrane format	Scientific Literature
2.	ALA4689778	Functional	Antagonist activity at human EP3 expressed in CHO cells assessed as suppression of sulprostone-induced inhibition of forskolin induced cAMP production measured after 30 mins by HTR-FRET assay	Homo sapiens	48	ALA4680377	cell-based format	Scientific Literature
3.	ALA4689779	ADME	Metabolic stability in human liver microsomes assessed as intrinsic clearance half life	Homo sapiens	48	ALA4680377	microsome format	Scientific Literature
4.	ALA4689780	ADME	Metabolic stability in rat liver microsomes assessed as intrinsic clearance half life	Rattus norvegicus	48	ALA4680377	microsome format	Scientific Literature
5.	ALA4689781	Physicochemical	Kinetic solubility of compound in PBS buffer		48	ALA4680377	small-molecule physicochemical format	Scientific Literature
6.	ALA4689782	Physicochemical	Kinetic solubility of compound at pH 2		48	ALA4680377	small-molecule physicochemical format	Scientific Literature
7.	ALA4689783	ADME	Apparent permeability across apical to basolateral side in dog MDCK cells	Canis lupus familiaris	20	ALA4680377	cell-based format	Scientific Literature
8.	ALA4689784	ADME	Clearance in Sprague-Dawley rat at 2 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis	Rattus norvegicus	3	ALA4680377	organism-based format	Scientific Literature
9.	ALA4689785	ADME	Volume of distribution at steady state in Sprague-Dawley rat at 2 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis	Rattus norvegicus	3	ALA4680377	organism-based format	Scientific Literature
10.	ALA4689786	ADME	Half life in Sprague-Dawley rat at 10 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis	Rattus norvegicus	3	ALA4680377	organism-based format	Scientific Literature
11.	ALA4689787	ADME	Cmax in Sprague-Dawley rat at 10 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis	Rattus norvegicus	5	ALA4680377	organism-based format	Scientific Literature
12.	ALA4689788	ADME	Oral bioavailability in Sprague-Dawley rat at 10 mg/kg measured up to 24 hrs by LC-MS/MS analysis	Rattus norvegicus	3	ALA4680377	organism-based format	Scientific Literature
13.	ALA4689789	ADME	Plasma protein binding in human	Homo sapiens	5	ALA4680377	cell-free format	Scientific Literature
14.	ALA4689790	ADME	Plasma protein binding in rat	Rattus norvegicus	5	ALA4680377	cell-free format	Scientific Literature
15.	ALA4689791	ADME	Glutathione reactivity in human liver S9 fractions assessed as GSH adduct formation measured after 60 mins in presence of NADPH by LC-MS/MS analysis	Homo sapiens	5	ALA4680377	subcellular format	Scientific Literature
16.	ALA4689792	ADME	Glutathione reactivity in rat liver S9 fractions assessed as GSH adduct formation measured after 60 mins in presence of NADPH by LC-MS/MS analysis	Rattus norvegicus	5	ALA4680377	subcellular format	Scientific Literature
17.	ALA4689793	Binding	Antagonist activity at EP3 in rat INS-1E cells assessed as reversal of sulprostone induced suppression of glucose-stimulated insulin secretion at 0.03 to 10 uM measured after 4 hrs by HTRF assay	Rattus norvegicus	1	ALA4680377	cell-based format	Scientific Literature
18.	ALA4689794	Functional	In vivo antagonist activity at EP3 in iv dosed Sprague-Dawley rat assessed as reversal of sulprostone-induced suppression of glucose-stimulated insulin secretion by measuring circulating insulin levels at 7 times Ki measured up to 30 mins by intravenous glucose tolerance test	Rattus norvegicus	1	ALA4680377	organism-based format	Scientific Literature
19.	ALA4689795	Functional	In vivo antagonist activity at EP3 in iv dosed Sprague-Dawley rat assessed as reversal of sulprostone-induced suppression of glucose-stimulated insulin secretion by measuring circulating insulin levels at 10 times Ki measured up to 30 mins by intravenous glucose tolerance test	Rattus norvegicus	1	ALA4680377	organism-based format	Scientific Literature
20.	ALA4689796	Binding	Binding affinity to rat EP3	Rattus norvegicus	1	ALA4680377	single protein format	Scientific Literature