# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4775173 | Functional | Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay | Homo sapiens | 7 | ALA4765463 | cell-based format | Scientific Literature | |
2. | ALA4775174 | Functional | Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay relative to control | Homo sapiens | 7 | ALA4765463 | cell-based format | Scientific Literature | |
3. | ALA4775175 | Functional | Agonist activity at human MC4R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay | Homo sapiens | 7 | ALA4765463 | cell-based format | Scientific Literature | |
4. | ALA4775176 | Functional | Agonist activity at human MC4R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split-luciferase reporter gene assay relative to control | Homo sapiens | 7 | ALA4765463 | cell-based format | Scientific Literature | |
5. | ALA4775177 | Binding | Selectivity index, ratio of EC50 for agonist activity at human MC3R expressed in HEK293 cells to IC50 for agonist activity at human MC4R expressed in HEK293 cells | Homo sapiens | 7 | ALA4765463 | cell-based format | Scientific Literature | |
6. | ALA4775178 | Binding | Selectivity index, ratio of EC50 for agonist activity at human MC4R expressed in HEK293 cells to IC50 for agonist activity at human MC3R expressed in HEK293 cells | Homo sapiens | 7 | ALA4765463 | cell-based format | Scientific Literature | |
7. | ALA4775179 | Binding | Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins | Homo sapiens | 17 | ALA4765463 | cell membrane format | Scientific Literature | |
8. | ALA4775180 | Binding | Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC4R expressed in HEK293 cell membranes incubated for 120 mins | Homo sapiens | 17 | ALA4765463 | cell membrane format | Scientific Literature | |
9. | ALA4775181 | Binding | Selectivity index, ratio of Ki for human MC3R expressed in HEK293 cell membranes to Ki for human MC4R expressed in HEK293 cell membranes | Homo sapiens | 17 | ALA4765463 | cell-based format | Scientific Literature |