| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4681572 | B | Binding affinity to GST-tagged ERRgamma LBD (unknown origin) using fluorescein PGC1alpha as coactivator incubated for 1 hr by LanthaScreen TR-FRET co-regulator assay | Homo sapiens | 45 | single protein format | Scientific Literature | ||
| 2. | ALA4681573 | B | Inverse agonist activity at Gal4-fused ERRgamma (unknown origin) expressed in human AD293 cells assessed as decrease in luciferase activity at 10 uM incubated for 24 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 45 | cell-based format | Scientific Literature | ||
| 3. | ALA4681574 | B | Binding affinity to GST-tagged ERRalpha LBD (unknown origin) using fluorescein PGC1alpha as coactivator incubated for 1 hr by LanthaScreen TR-FRET co-regulator assay | Homo sapiens | 21 | single protein format | Scientific Literature | ||
| 4. | ALA4681575 | B | Binding affinity to GST-tagged ERRbeta LBD (unknown origin) using fluorescein PGC1alpha as coactivator incubated for 1 hr by LanthaScreen TR-FRET co-regulator assay | Homo sapiens | 21 | single protein format | Scientific Literature | ||
| 5. | ALA4681576 | B | Binding affinity to GST-tagged ERalpha LBD (unknown origin) using fluorescein PGC1alpha as coactivator incubated for 1 hr by LanthaScreen TR-FRET co-regulator assay | Homo sapiens | 21 | single protein format | Scientific Literature | ||
| 6. | ALA4681577 | A | Inhibition of CYP1A2 in human liver microsomes assessed as reduction in phenacetin O-deethylase activity at 10 uM preincubated for 5 mins followed by addition of NADPH-regenerating system and measured after 15 mins by LC-MS/MS analysis relative to control | Homo sapiens | 6 | microsome format | Scientific Literature | ||
| 7. | ALA4681578 | A | Inhibition of CYP2C9 in human liver microsomes assessed as reduction in tolbutamide 4-hydroxylase activity at 10 uM preincubated for 5 mins followed by addition of NADPH-regenerating system and measured after 15 mins by LC-MS/MS analysis relative to control | Homo sapiens | 6 | microsome format | Scientific Literature | ||
| 8. | ALA4681579 | A | Inhibition of CYP2C19 in human liver microsomes assessed as reduction in S-mephenytoin 4-hydroxylase activity at 10 uM preincubated for 5 mins followed by addition of NADPH-regenerating system and measured after 15 mins by LC-MS/MS analysis relative to control | Homo sapiens | 6 | microsome format | Scientific Literature | ||
| 9. | ALA4681580 | A | Inhibition of CYP2D6 in human liver microsomes assessed as reduction in dextromethorphan O-demethylase activity at 10 uM preincubated for 5 mins followed by addition of NADPH-regenerating system and measured after 15 mins by LC-MS/MS analysis relative to control | Homo sapiens | 6 | microsome format | Scientific Literature | ||
| 10. | ALA4681581 | A | Inhibition of CYP3A4 in human liver microsomes assessed as reduction in midazolam 1-hydroxylase activity at 10 uM preincubated for 5 mins followed by addition of NADPH-regenerating system and measured after 15 mins by LC-MS/MS analysis relative to control | Homo sapiens | 6 | microsome format | Scientific Literature | ||
| 11. | ALA4681582 | A | Metabolic stability in human liver microsome assessed as parent compound remaining at 1 uM incubated for 30 mins in presence of NADPH generating system by LC-MS/MS analysis | Homo sapiens | 6 | microsome format | Scientific Literature | ||
| 12. | ALA4681583 | A | Metabolic stability in rat liver microsome assessed as parent compound remaining at 1 uM incubated for 30 mins in presence of NADPH generating system by LC-MS/MS analysis | Rattus norvegicus | 6 | microsome format | Scientific Literature | ||
| 13. | ALA4681584 | A | Effective permeability of compound at 10 uM in PBS buffer at pH 7.4 after 5 hrs by LC-MS/MS analysis based PAMPA method | 6 | assay format | Scientific Literature | |||
| 14. | ALA4681585 | B | Inhibition of human ERG measured after 4 hrs by fluorescence polarization assay | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 15. | ALA4681586 | A | Clearance in Sprague-Dawley rat at 10 mg/kg, po or 1 mg/kg, iv measured upto 8 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 16. | ALA4681587 | A | Volume of distribution at steady state in Sprague-Dawley rat at 10 mg/kg, po or 1 mg/kg, iv measured upto 8 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4681588 | A | Half-life in Sprague-Dawley rat at 10 mg/kg, po or 1 mg/kg, iv measured upto 8 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4681589 | A | Oral bioavailability in Sprague-Dawley rat at 10 mg/kg, administered via gavage measured upto 8 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4681590 | B | Inverse agonist activity at ERRgamma in human CAL-62 cells assessed as reduction in ERRgamma protein levels incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 20. | ALA4681591 | B | Inverse agonist activity at ERRgamma in human CAL-62 cells assessed as increase in phosphorylation of p44 MAPK at 10 to 20 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature |
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