| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4735019 | B | Inhibition of recombinant human C-terminal His-tagged ACC1 (1 to 2383 residues) expressed in baculovirus infected Sf9 insect cells at 5 uM preincubated for 15 mins followed by substrate addition and measured after 60 mins by ADP-glo luminescence assay relative to control | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 2. | ALA4735020 | B | Inhibition of recombinant human C-terminal His-tagged ACC1 (1 to 2383 residues) expressed in baculovirus infected Sf9 insect cells at 0.1 uM preincubated for 15 mins followed by substrate addition and measured after 60 mins by ADP-glo luminescence assay relative to control | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 3. | ALA4735021 | B | Inhibition of recombinant human C-terminal His-tagged ACC1 (1 to 2383 residues) expressed in baculovirus infected Sf9 insect cells preincubated for 15 mins followed by substrate addition and measured after 60 mins by ADP-glo luminescence assay | Homo sapiens | 23 | cell-based format | Scientific Literature | ||
| 4. | ALA4735022 | F | Antiproliferative activity against human A549 cells assessed as cell growth inhibition at 10 uM after 72 hrs by MTT assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4735023 | F | Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition at 10 uM after 72 hrs by MTT assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4735024 | F | Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition at 10 uM after 72 hrs by MTT assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4735025 | F | Antiproliferative activity against human A549 cells assessed as cell growth inhibition after 72 hrs by MTT assay | Homo sapiens | 23 | cell-based format | Scientific Literature | ||
| 8. | ALA4735026 | F | Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition after 72 hrs by MTT assay | Homo sapiens | 23 | cell-based format | Scientific Literature | ||
| 9. | ALA4735027 | F | Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition after 72 hrs by MTT assay | Homo sapiens | 23 | cell-based format | Scientific Literature | ||
| 10. | ALA4735028 | A | Cytotoxicity against HUVEC assessed as cell viability at 100 uM after 72 hrs by MTT assay relative to control | Homo sapiens | 23 | cell-based format | Scientific Literature | ||
| 11. | ALA4735029 | F | Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition by MTT assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 12. | ALA4735030 | B | Inhibition of ACC1 in human HepG2 cells assessed as reduction in intracellular malonyl-CoA level measured after 48 hrs by ELISA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4735031 | B | Inhibition of ACC1 in human HepG2 cells assessed as reduction in intracellular triglyceride level measured after 48 hrs by GPO-PAP method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4735032 | B | Inhibition of ACC1 in human HepG2 cells assessed as reduction in intracellular malonyl-CoA level at 10 uM measured after 48 hrs by ELISA relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4735033 | B | Inhibition of ACC1 in human HepG2 cells assessed as reduction in intracellular triglyceride level at 10 uM measured after 48 hrs by GPO-PAP method relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4735034 | F | Antiproliferative activity against human HepG2 cells assessed as cell viability at 0.5 uM measured after 5 days in presence of 10 uM palmitate by MTT assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4735035 | F | Antiproliferative activity against human HepG2 cells assessed as cell viability at 0.5 uM measured after 5 days in presence of 25 uM palmitate by MTT assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4735036 | F | Antiproliferative activity against human HepG2 cells assessed as cell viability at 0.5 uM measured after 5 days by MTT assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4735037 | F | Cell cycle arrest in human HepG2 cells assessed as accumulation at G0/G1 phase measured after 48 hrs by propidium iodide staining based flow cytometry | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4735038 | F | Cell cycle arrest in human HepG2 cells assessed as accumulation at G0/G1 phase at 1 uM measured after 48 hrs by propidium iodide staining based flow cytometry (Rvb = 56.24%) | Homo sapiens | 1 | cell-based format | Scientific Literature |
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