| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4670893 | B | Binding affinity to BTN3A1 in human PBMC-derived Vgamma9/Vdelta2 T cells assessed as induction of Vgamma9/Vdelta2 T cell mediated T-24 cell lysis co-expressing GFP at 10 pM preincubated 4 hrs followed by compound washout and subsequent Vgamma9Vdelta2 T cell addition at 8:1 effector/target ratio and measured after 18 hrs by fluorescence based assay | Homo sapiens | 5 | tissue-based format | Scientific Literature | ||
| 2. | ALA4670894 | B | Binding affinity to BTN3A1 in human PBMC-derived Vgamma9/Vdelta2 T cells assessed as induction of Vgamma9/Vdelta2 T cell mediated T-24 cell lysis co-expressing GFP at 10 pM preincubated 4 hrs followed by compound washout and subsequent Vgamma9Vdelta2 T cell addition at 1:1 effector/target ratio and measured after 18 hrs by fluorescence based assay | Homo sapiens | 5 | tissue-based format | Scientific Literature | ||
| 3. | ALA4670895 | A | Cytotoxicity against human T-24 cells co-expressing GFP assessed as reduction in cell viability at 10 pM after 4 hrs by eFluor 780 fixable viability dye based fluorescence assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 4. | ALA4670896 | B | Potency index, ratio of HMBPP EC50 to test compound EC50 for activation of of BTN3A1 in human PBMC-derived Vgamma9/Vdelta2 T cells | Homo sapiens | 2 | tissue-based format | Scientific Literature | ||
| 5. | ALA4670897 | B | Binding affinity to BTN3A1 in human PBMC-derived Vgamma9/Vdelta2 T cells assessed as increase in CD69/CD25 level incubated for overnight by flow cytometric analysis | Homo sapiens | 10 | tissue-based format | Scientific Literature | ||
| 6. | ALA4670901 | A | Stability of compound in human serum at 5 mg and measured at 30 mins interval for up to 12 hrs by 31PNMR analysis | Homo sapiens | 2 | cell-free format | Scientific Literature | ||
| 7. | ALA4670904 | F | Activation of human PBMC derived CD-8 positive cells assessed as increase in alphabeta T cells at 0.1 to 10000 nM by Alexa Flour A88a staining based flow cytometry | Homo sapiens | 2 | cell-based format | Scientific Literature |
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