# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4735343 | B | Inhibition of human EZH2 (2 to 746 residues) expressed in baculovirus infected insect cells using histone H3 as substrate preincubated for 10 mins followed by S-adenosyl-L-[methyl-3H]methionine and measured after 60 mins by radiometric HotSpot assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
2. | ALA4735345 | B | Inhibition of human FLAG-tagged EZH2 using H3K27me as substrate in presence of [3H]-SAM incubated for 30 mins by Cheng-Prusoff analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
3. | ALA4735346 | B | Inhibition of human FLAG-tagged EZH2 Y641 mutant using H3K27me2 as substrate in presence of [3H]-SAM incubated for 30 mins by Cheng-Prusoff analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
4. | ALA4735347 | A | AUC in SCID-beige mouse xenografted with human Pfeiffer cells at 50 mg/kg, ip by HPLC/MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
5. | ALA4735348 | A | Cmax in blood of SCID-beige mouse xenografted with human Pfeiffer cells at 50 mg/kg, ip by HPLC/MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
6. | ALA4735349 | A | Drug exposure in tumor of SCID-beige mouse xenografted with human Pfeiffer cells at 50 mg/kg, ip by HPLC/MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
7. | ALA4735350 | A | Cmax in tumor of SCID-beige mouse xenografted with human Pfeiffer cells at 50 mg/kg, ip by HPLC/MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
8. | ALA4735358 | F | Antitumor activity against human Pfeiffer-FP1 cells xenografted in CB17 scid-beige mouse assessed as tumor growth inhibition at 50 mg/kg, IP administered once daily for 36 days by digital caliper method relative to control | Homo sapiens | 1 | organism-based format | Scientific Literature |