# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4722683 | ADME | Cytotoxicity against HFF assessed as inhibition of cell proliferation by MTS assay | Homo sapiens | 4 | ALA4715843 | cell-based format | Scientific Literature | |
2. | ALA4722684 | ADME | Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation by MTS assay | Homo sapiens | 4 | ALA4715843 | cell-based format | Scientific Literature | |
3. | ALA4722685 | Functional | Cytotoxicity against human A-375 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTS assay | Homo sapiens | 4 | ALA4715843 | cell-based format | Scientific Literature | |
4. | ALA4722686 | Unassigned | Drug metabolism in pH 7.4 phosphate buffer assessed as nitric oxide release at 100 uM measured after 2 hrs by Griess reagent based colorimetric method | 5 | ALA4715843 | assay format | Scientific Literature | ||
5. | ALA4722687 | Unassigned | Drug metabolism in pH 7.4 phosphate buffer assessed as nitric oxide release at 100 uM measured after 48 hrs by Griess reagent based colorimetric method | 5 | ALA4715843 | assay format | Scientific Literature | ||
6. | ALA4722688 | Binding | Displacement of FAM-labeled 5-GpYLPQTV-NH2 from recombinant GST-tagged STAT3 (unknown origin) preincubated for 30 mins followed by FAM-labeled 5-GpYLPQTV-NH2 addition and measured after 30 mins by fluorescence assay | Homo sapiens | 3 | ALA4715843 | single protein format | Scientific Literature | |
7. | ALA4722689 | Functional | Potentiation of compound II-induced cytotoxicity against human A375 cells assessed as compound II IC50 at 12.5 uM measured after 48 hrs by MTS assay (Rvb = 16.2 +/- 1.6 uM) | Homo sapiens | 1 | ALA4715843 | cell-based format | Scientific Literature | |
8. | ALA4722731 | Functional | Antiproliferative activity against human SB-590885-sensitive 451Lu cells assessed as reduction in cell viability measured after 48 hrs by MTS assay | Homo sapiens | 4 | ALA4715843 | tissue-based format | Scientific Literature | |
9. | ALA4722743 | Binding | Inhibition of STAT3 phosphorylation at Y705 residue in human SB-590885-resistant 451Lu cells measured after 12 hrs by Western blot analysis | Homo sapiens | 5 | ALA4715843 | tissue-based format | Scientific Literature | |
10. | ALA4722744 | Binding | Inhibition of STAT3 phosphorylation at S727 residue in human SB-590885-resistant 451Lu cells measured after 12 hrs by Western blot analysis | Homo sapiens | 5 | ALA4715843 | tissue-based format | Scientific Literature | |
11. | ALA4722745 | Binding | Inhibition of STAT3 phosphorylation at Y705 residue in human SB-590885-sensitive 451Lu cells measured after 12 hrs by Western blot analysis | Homo sapiens | 5 | ALA4715843 | tissue-based format | Scientific Literature | |
12. | ALA4722746 | Binding | Inhibition of STAT3 phosphorylation at S727 residue in human SB-590885-sensitive 451Lu cells measured after 12 hrs by Western blot analysis | Homo sapiens | 5 | ALA4715843 | tissue-based format | Scientific Literature | |
13. | ALA4722747 | Binding | Inhibition of STAT3 in human SB-590885-sensitive 451Lu cells assessed as reduction in PAX3 expression measured after 12 hrs by Western blot analysis | Homo sapiens | 5 | ALA4715843 | tissue-based format | Scientific Literature | |
14. | ALA4722748 | Binding | Inhibition of STAT3 in human SB-590885-resistant 451Lu cells assessed as reduction in PAX3 expression measured after 12 hrs by Western blot analysis | Homo sapiens | 5 | ALA4715843 | tissue-based format | Scientific Literature | |
15. | ALA4722749 | Binding | Inhibition of STAT3 phosphorylation at Y705 residue in human SB-590885-resistant MEL1617 cells at 10 to 25 uM measured after 12 hrs by Western blot analysis | Homo sapiens | 5 | ALA4715843 | tissue-based format | Scientific Literature | |
16. | ALA4722750 | Binding | Inhibition of STAT3 phosphorylation at S727 residue in human SB-590885-resistant MEL1617 cells at 10 to 25 uM measured after 12 hrs by Western blot analysis | Homo sapiens | 5 | ALA4715843 | tissue-based format | Scientific Literature | |
17. | ALA4722751 | Binding | Inhibition of STAT3 phosphorylation at Y705 residue in human SB-590885-sensitive MEL1617 cells at 10 to 25 uM measured after 12 hrs by Western blot analysis | Homo sapiens | 5 | ALA4715843 | tissue-based format | Scientific Literature | |
18. | ALA4722752 | Binding | Inhibition of STAT3 phosphorylation at S727 residue in human SB-590885-sensitive MEL1617 cells at 10 to 25 uM measured after 12 hrs by Western blot analysis | Homo sapiens | 5 | ALA4715843 | tissue-based format | Scientific Literature | |
19. | ALA4722753 | Binding | Inhibition of STAT3 in human SB-590885-sensitive MEL1617 cells assessed as reduction in PAX3 expression at 10 to 25 uM measured after 12 hrs by Western blot analysis | Homo sapiens | 5 | ALA4715843 | tissue-based format | Scientific Literature | |
20. | ALA4722754 | Binding | Inhibition of STAT3 in human SB-590885-resistant MEL1617 cells assessed as reduction in PAX3 expression at 10 to 25 uM measured after 12 hrs by Western blot analysis | Homo sapiens | 5 | ALA4715843 | tissue-based format | Scientific Literature |