# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4677398 | B | Inhibition of human PD-L1 cocultured in PBMC cells assessed as inhibition of PD1/PDL1 interaction mediated increase in IFN-gamma secretion at 1 uM incubated for 72 hrs by ELISA | Homo sapiens | 2 | ALA4673285 | cell-based format | Scientific Literature | |
2. | ALA4677413 | A | Cytotoxicity against human Raji cells assessed as reduction in cell viability at 100 uM incubated for 24 hrs by Cell-titer glo Luminescent assay | Homo sapiens | 2 | ALA4673285 | cell-based format | Scientific Literature | |
3. | ALA4677415 | A | Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability at 3.125 to 100 uM incubated for 24 hrs by Cell-titer glo Luminescent assay | Mus musculus | 4 | ALA4673285 | cell-based format | Scientific Literature | |
4. | ALA4677418 | A | Cytotoxicity against human PBMC cells assessed as reduction in cell viability at 6.3 uM incubated for 24 hrs by Cell-titer glo Luminescent assay | Homo sapiens | 5 | ALA4673285 | cell-based format | Scientific Literature | |
5. | ALA4677419 | A | Cytotoxicity against human PBMC cells assessed as reduction in cell viability up to 100 uM incubated for 24 hrs by Cell-titer glo Luminescent assay | Homo sapiens | 4 | ALA4673285 | cell-based format | Scientific Literature | |
6. | ALA4677424 | B | Inhibition of human PD-L1 cocultured in PBMC cells assessed as inhibition of PD1/PDL1 interaction mediated increase in IFN-gamma secretion at 0.1 uM incubated for 72 hrs by ELISA | Homo sapiens | 4 | ALA4673285 | cell-based format | Scientific Literature | |
7. | ALA4677425 | B | Binding affinity to human PD-L1 expressed in CHOK1 cells assessed as inhibition of PD1/PDL1 protein-protein interaction at 500 nM incubated for 30 mins by flow cytometry analysis relative to control | Homo sapiens | 5 | ALA4673285 | cell-based format | Scientific Literature | |
8. | ALA4677426 | B | Binding affinity to human PD-L1 expressed in CHOK1 cells assessed as inhibition of PD1/PDL1 protein-protein interaction at 500 nM incubated for 30 mins by flow cytometry analysis | Homo sapiens | 5 | ALA4673285 | cell-based format | Scientific Literature | |
9. | ALA4677427 | B | Binding affinity to biotinylated human AVI-PD-L1 by biolayer interferometry | Homo sapiens | 5 | ALA4673285 | single protein format | Scientific Literature | |
10. | ALA4677428 | B | Binding affinity to biotinylated human AVI-PD-L1 assessed as dissociation constant by biolayer interferometry | Homo sapiens | 5 | ALA4673285 | single protein format | Scientific Literature | |
11. | ALA4677429 | B | Binding affinity to biotinylated human AVI-PD-L1 assessed as association constant by biolayer interferometry | Homo sapiens | 5 | ALA4673285 | single protein format | Scientific Literature | |
12. | ALA4677430 | B | Binding affinity to human Fc-tagged LAG3 at 500 nM measured after 600 sec by biolayer interferometry | Homo sapiens | 1 | ALA4673285 | single protein format | Scientific Literature | |
13. | ALA4677431 | B | Binding affinity to human Fc-tagged CD27 at 500 nM measured after 600 sec by biolayer interferometry | Homo sapiens | 1 | ALA4673285 | single protein format | Scientific Literature | |
14. | ALA4677432 | B | Binding affinity to human Fc-tagged TIM3 at 500 nM measured after 600 sec by biolayer interferometry | Homo sapiens | 1 | ALA4673285 | single protein format | Scientific Literature | |
15. | ALA4677433 | B | Binding affinity to human Fc-tagged CD47 at 500 nM measured after 600 sec by biolayer interferometry | Homo sapiens | 1 | ALA4673285 | single protein format | Scientific Literature | |
16. | ALA4677434 | B | Binding affinity to human Fc-tagged PDL2 at 500 nM measured after 600 sec by biolayer interferometry | Homo sapiens | 1 | ALA4673285 | single protein format | Scientific Literature | |
17. | ALA4677435 | B | Binding affinity to human Fc-tagged PDL1 at 500 nM measured after 600 sec by biolayer interferometry | Homo sapiens | 1 | ALA4673285 | single protein format | Scientific Literature | |
18. | ALA4677436 | B | Binding affinity to human Fc-tagged PD1 at 500 nM measured after 600 sec by biolayer interferometry | Homo sapiens | 1 | ALA4673285 | single protein format | Scientific Literature | |
19. | ALA4677437 | B | Inhibition of PD1-Tag2/PD-L1-Tag1 (unknown origin) protein-protein interaction preincubated for 15 mins followed by addition of anti-Tag1-Eu3+ and anti-Tag2-XL665 measured after 2.5 hrs by HTRF assay | Homo sapiens | 37 | ALA4673285 | protein complex format | Scientific Literature |