| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4682224 | B | Inhibition of recombinant full-length human FLAG-tagged ATM assessed as reduction in p53 S15 phosphorylation incubated for 30 mins by ELISA | Homo sapiens | 41 | single protein format | Scientific Literature | ||
| 2. | ALA4682225 | B | Inhibition of ATM in human MCF7 cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation incubated for 1 hr by ICW assay | Homo sapiens | 41 | cell-based format | Scientific Literature | ||
| 3. | ALA4682226 | P | Kinetic solubility in pH 7.4 PBS buffer by LC-UV assay | 41 | small-molecule physicochemical format | Scientific Literature | |||
| 4. | ALA4682227 | A | Efflux ratio in MDCK-MDR1 cells incubated for 1 hr by LC-MS/MS analysis | Canis lupus familiaris | 41 | cell-based format | Scientific Literature | ||
| 5. | ALA4682228 | A | Apparent permeability in MDCK-MDR1 cells incubated for 1 hr by LC-MS/MS analysis | Canis lupus familiaris | 41 | cell-based format | Scientific Literature | ||
| 6. | ALA4682229 | A | Intrinsic clearance in mouse liver microsomes at 1 uM in presence of NADPH incubated up to 40 mins by LC-MS/MS analysis | Mus musculus | 34 | microsome format | Scientific Literature | ||
| 7. | ALA4682230 | B | Binding affinity to human Vps34 expressed in mammalian expression system | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 8. | ALA4682231 | A | Intrinsic clearance in mouse hepatocytes | Mus musculus | 26 | cell-based format | Scientific Literature | ||
| 9. | ALA4682232 | B | Inhibition of ATR in human HeLa cells incubated for 4 hrs | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 10. | ALA4682233 | B | Inhibition of recombinant full-length human VPS34 incubated for 60 mins by ADP-Glo kinase assay | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 11. | ALA4682234 | B | Inhibition of DNA-PK isolated from human HeLa cells assessed as reduction in p53 Ser15 phosphorylation by HTRF assay | Homo sapiens | 7 | assay format | Scientific Literature | ||
| 12. | ALA4682235 | A | AUC/dose in C57BL/6J mouse plasma at 3 mg/kg, iv administered as single dose by LC-MS/MS analysis | Mus musculus | 8 | organism-based format | Scientific Literature | ||
| 13. | ALA4682236 | A | AUC/dose in C57BL/6J mouse brain at 3 mg/kg, iv administered as single dose by LC-MS/MS analysis | Mus musculus | 8 | organism-based format | Scientific Literature | ||
| 14. | ALA4682237 | A | Plasma clearance in C57BL/6J mouse at 3 mg/kg, iv administered as single dose by LC-MS/MS analysis | Mus musculus | 8 | organism-based format | Scientific Literature | ||
| 15. | ALA4682238 | A | Volume of distribution at steady state in C57BL/6J mouse at 3 mg/kg, iv administered as single dose by LC-MS/MS analysis | Mus musculus | 8 | organism-based format | Scientific Literature | ||
| 16. | ALA4682239 | A | Half life in C57BL/6J mouse at 3 mg/kg, iv administered as single dose by LC-MS/MS analysis | Mus musculus | 8 | organism-based format | Scientific Literature | ||
| 17. | ALA4682240 | A | Ratio of AUC/dose in brain to plasma of C57BL/6J mouse at 3 mg/kg, iv administered as single dose by LC-MS/MS analysis | Mus musculus | 8 | organism-based format | Scientific Literature | ||
| 18. | ALA4682241 | A | Unbound brain-to-plasma concentration ratio in C57BL/6J mouse at 3 mg/kg, iv administered as single dose by LC-MS/MS analysis | Mus musculus | 8 | organism-based format | Scientific Literature | ||
| 19. | ALA4682242 | A | AUC/dose in C57BL/6J mouse plasma at 10 mg/kg, po by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4682243 | A | Oral bioavailability in C57BL/6J mouse plasma at 10 mg/kg by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature |
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