| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4767744 | F | Antiviral activity against VSVG/wild-type HIV-1 infected in human HEK 293T cells assessed as inhibition of virus replication preincubated with cells for 15 mins prior to viral infection and measured at 48 hrs post-infection by luciferase reporter gene assay | Human immunodeficiency virus 1 | 61 | ALA4765253 | organism-based format | Scientific Literature | |
| 2. | ALA4767745 | A | Cytotoxicity against human HEK 293T cells assessed as reduction in cell viability measured after 48 hrs by Celltiter-glo assay | Homo sapiens | 61 | ALA4765253 | cell-based format | Scientific Literature | |
| 3. | ALA4767746 | T | Selectivity index, ratio of CC50 for human HEK 293T cells to EC50 for VSVG/wild type HIV1 infected in human HEK 293T cells | 27 | ALA4765253 | cell-based format | Scientific Literature | ||
| 4. | ALA4767747 | B | Inhibition of HIV-1 reverse transcriptase RNA-dependent DNA polymerase activity assessed as reduction in dTTP incorporation using poly(rA)/oligo(dT) as template/primer incubated for 1 hr followed by transferring into streptavidin plate for 1 hr by absorbance based analysis | Human immunodeficiency virus 1 | 6 | ALA4765253 | assay format | Scientific Literature | |
| 5. | ALA4767748 | F | Antiviral activity against VSVG/HIV-1 harboring reverse transcriptase K103N mutant infected in human HEK 293T cells assessed as inhibition of virus replication preincubated with cells for 15 mins prior to viral infection and measured at 48 hrs post-infection by luciferase reporter gene assay | Human immunodeficiency virus 1 | 6 | ALA4765253 | organism-based format | Scientific Literature | |
| 6. | ALA4767749 | B | Inhibition of RNase H activity of HIV-1 reverse transcriptase using DNA/RNA hybrid as substrate incubated for 30 mins by fluorescence based analysis | Human immunodeficiency virus 1 | 6 | ALA4765253 | assay format | Scientific Literature | |
| 7. | ALA4767752 | A | Cytotoxicity against human HEK 293T cells assessed as cell viability at 30 uM measured after 48 hrs by Celltiter-glo assay | Homo sapiens | 30 | ALA4765253 | cell-based format | Scientific Literature | |
| 8. | ALA4767756 | F | Antiviral activity against VSVG/HIV-1 harboring reverse transcriptase Y181C mutant infected in human HEK 293T cells assessed as inhibition of virus replication preincubated with cells for 15 mins prior to viral infection and measured at 48 hrs post-infection by luciferase reporter gene assay | Human immunodeficiency virus 1 | 6 | ALA4765253 | organism-based format | Scientific Literature | |
| 9. | ALA4767757 | F | Antiviral activity against VSVG/HIV-1 harboring reverse transcriptase K103N/Y181C double mutant infected in human HEK 293T cells assessed as inhibition of virus replication preincubated with cells for 15 mins prior to viral infection and measured at 48 hrs post-infection by luciferase reporter gene assay | Human immunodeficiency virus 1 | 6 | ALA4765253 | organism-based format | Scientific Literature | |
| 10. | ALA4767758 | F | Antiviral activity against VSVG/HIV-1 harboring reverse transcriptase L100I/K103N double mutant infected in human HEK 293T cells assessed as inhibition of virus replication preincubated with cells for 15 mins prior to viral infection and measured at 48 hrs post-infection by luciferase reporter gene assay | Human immunodeficiency virus 1 | 6 | ALA4765253 | organism-based format | Scientific Literature | |
| 11. | ALA4767759 | F | Antiviral activity against VSVG/HIV-1 harboring reverse transcriptase Y188L mutant infected in human HEK 293T cells assessed as inhibition of virus replication preincubated with cells for 15 mins prior to viral infection and measured at 48 hrs post-infection by luciferase reporter gene assay | Human immunodeficiency virus 1 | 6 | ALA4765253 | organism-based format | Scientific Literature | |
| 12. | ALA4767760 | F | Antiviral activity against VSVG/HIV-1 harboring reverse transcriptase G190A/K103N double mutant infected in human HEK 293T cells assessed as inhibition of virus replication preincubated with cells for 15 mins prior to viral infection and measured at 48 hrs post-infection by luciferase reporter gene assay | Human immunodeficiency virus 1 | 6 | ALA4765253 | organism-based format | Scientific Literature | |
| 13. | ALA4767761 | F | Antiviral activity against VSVG/HIV-1 harboring reverse transcriptase V108I/K103N double mutant infected in human HEK 293T cells assessed as inhibition of virus replication preincubated with cells for 15 mins prior to viral infection and measured at 48 hrs post-infection by luciferase reporter gene assay | Human immunodeficiency virus 1 | 6 | ALA4765253 | organism-based format | Scientific Literature | |
| 14. | ALA4767762 | F | Selectivity index, ratio of EC50 for antiviral activity against VSVG/HIV-1 harboring reverse transcriptase K103N mutant infected in human HEK 293T cells to EC50 for antiviral activity against VSVG/wild type HIV-1 infected in human HEK293T cells | Human immunodeficiency virus 1 | 6 | ALA4765253 | cell-based format | Scientific Literature | |
| 15. | ALA4767763 | F | Selectivity index, ratio of EC50 for antiviral activity against VSVG/HIV-1 harboring reverse transcriptase Y181C mutant infected in human HEK 293T cells to EC50 for antiviral activity against VSVG/wild type HIV-1 infected in human HEK293T cells | Human immunodeficiency virus 1 | 6 | ALA4765253 | cell-based format | Scientific Literature | |
| 16. | ALA4767764 | F | Selectivity index, ratio of EC50 for antiviral activity against VSVG/HIV-1 harboring reverse transcriptase K103N/Y181C double mutant infected in human HEK 293T cells to EC50 for antiviral activity against VSVG/wild type HIV-1 infected in human HEK293T cells | Human immunodeficiency virus 1 | 6 | ALA4765253 | cell-based format | Scientific Literature | |
| 17. | ALA4767765 | F | Selectivity index, ratio of EC50 for antiviral activity against VSVG/HIV-1 harboring reverse transcriptase L100I/K103N double mutant infected in human HEK 293T cells to EC50 for antiviral activity against VSVG/wild type HIV-1 infected in human HEK293T cells | Human immunodeficiency virus 1 | 6 | ALA4765253 | cell-based format | Scientific Literature | |
| 18. | ALA4767766 | F | Selectivity index, ratio of EC50 for antiviral activity against VSVG/HIV-1 harboring reverse transcriptase Y188L mutant infected in human HEK 293T cells to EC50 for antiviral activity against VSVG/wild type HIV-1 infected in human HEK293T cells | Human immunodeficiency virus 1 | 6 | ALA4765253 | cell-based format | Scientific Literature | |
| 19. | ALA4767767 | F | Selectivity index, ratio of EC50 for antiviral activity against VSVG/HIV-1 harboring reverse transcriptase G190A/K103N double mutant infected in human HEK 293T cells to EC50 for antiviral activity against VSVG/wild type HIV-1 infected in human HEK293T cells | Human immunodeficiency virus 1 | 6 | ALA4765253 | cell-based format | Scientific Literature | |
| 20. | ALA4767768 | F | Selectivity index, ratio of EC50 for antiviral activity against VSVG/HIV-1 harboring reverse transcriptase V108I/K103N double mutant infected in human HEK 293T cells to EC50 for antiviral activity against VSVG/wild type HIV-1 infected in human HEK293T cells | Human immunodeficiency virus 1 | 6 | ALA4765253 | cell-based format | Scientific Literature |
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