| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4768523 | B | Inhibition of human recombinant lysosomal GCase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 45 mins followed by substrate addition and measured after 30 mins by fluorescence spectrophotometric assay | Homo sapiens | 14 | single protein format | Scientific Literature | ||
| 2. | ALA4768524 | B | Competitive inhibition of human recombinant lysosomal GCase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 45 mins followed by substrate addition and measured after 30 mins by fluorescence spectrophotometry based Lineweaver-Burk plot analysis | Homo sapiens | 10 | single protein format | Scientific Literature | ||
| 3. | ALA4768526 | B | Inhibition of human recombinant lysosomal alpha-GalA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 mins followed by substrate addition and measured after 30 mins by fluorescence spectrophotometric assay | Homo sapiens | 16 | single protein format | Scientific Literature | ||
| 4. | ALA4768527 | B | Competitive inhibition of human recombinant lysosomal alpha-GalA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 mins followed by substrate addition and measured after 30 mins by fluorescence spectrophotometry based Lineweaver-Burk plot analysis | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 5. | ALA4768529 | B | Chaperone activity at alpha-GalA R301G mutant in Fabry patient derived fibroblasts assessed as increase in intracellular alpha-GalA activity at 10 uM measured after 5 days by 4-methylumbelliferyl-alpha-D-glucopyranoside substrate based assay relative to control | Homo sapiens | 4 | tissue-based format | Scientific Literature | ||
| 6. | ALA4768530 | B | Chaperone activity at alpha-GalA R301G mutant in Fabry patient derived fibroblasts assessed as increase in intracellular alpha-GalA activity at 2.5 uM measured after 5 days by 4-methylumbelliferyl-alpha-D-glucopyranoside substrate based assay relative to control | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 7. | ALA4768531 | B | Chaperone activity at alpha-GalA R301G mutant in Fabry patient derived fibroblasts assessed as increase in intracellular alpha-GalA activity measured after 5 days by 4-methylumbelliferyl-alpha-D-glucopyranoside substrate based assay | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 8. | ALA4768532 | A | Cytotoxicity against Fabry patient derived fibroblasts harboring alpha-GalA R301G mutant assessed as reduction in cell viability at 50 uM | Homo sapiens | 1 | cell-based format | Scientific Literature |
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