| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4774694 | F | Antagonist activity at human alpha1A receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 2. | ALA4774695 | F | Antagonist activity at human alpha1B receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 3. | ALA4774696 | F | Antagonist activity at human alpha1D receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 4. | ALA4774697 | B | Inhibition of 5-alpha reductase in rat liver microsomes assessed as inhibition of DHT formation using testosterone as substrate incubated for 10 mins by NADPH assay | Rattus norvegicus | 6 | microsome format | Scientific Literature | ||
| 5. | ALA4774698 | A | Tmax in Sprague-Dawley rat at 20 mg/kg, ip | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA4774699 | A | Cmax in Sprague-Dawley rat at 20 mg/kg, ip | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA4774700 | A | AUC (0 to t) in Sprague-Dawley rat at 20 mg/kg, ip | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA4774701 | A | AUC (0 to infinity) in Sprague-Dawley rat at 20 mg/kg, ip | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA4774702 | A | MRT in Sprague-Dawley rat at 20 mg/kg, ip | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA4774703 | A | Half life in Sprague-Dawley rat at 20 mg/kg, ip | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA4774704 | A | Apparent clearance in Sprague-Dawley rat at 20 mg/kg, ip | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4774705 | A | Bioavailability in Sprague-Dawley rat at 20 mg/kg, ip | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4774706 | A | Tmax in Sprague-Dawley rat at 2 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4774707 | A | Cmax in Sprague-Dawley rat at 2 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4774708 | A | AUC (0 to t) in Sprague-Dawley rat at 2 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4774709 | A | AUC (0 to infinity) in Sprague-Dawley rat at 2 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4774710 | A | MRT in Sprague-Dawley rat at 2 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4774711 | A | Apparent clearance in Sprague-Dawley rat at 2 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4774712 | A | Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability at 0.390625 to 100 uM incubated for 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4774713 | A | Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability at 0.390625 to 100 uM incubated for 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature |
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