# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4701318 | ADME | Cytotoxicity against human SK-MEL-28 cells assessed as reduction in cell viability preincubated for 16 hrs in dark condition subsequently incubated for 48 hrs by alamar blue assay | Homo sapiens | 6 | ALA4699461 | cell-based format | Scientific Literature | |
2. | ALA4701319 | Functional | Phototoxicity against human SK-MEL-28 cells assessed as reduction in cell viability preincubated for 16 hrs followed by irradiated with 100 J/cm2 400 to 700 nanometer visible light for 40 mins and measured after 48 hrs by alamar blue assay | Homo sapiens | 6 | ALA4699461 | cell-based format | Scientific Literature | |
3. | ALA4701320 | Unassigned | Phototherapeutic index, ratio of EC50 for cytotoxicity against human SK-MEL-28 cells in dark condition to EC50 for phototoxicity against human SK-MEL-28 cells preincubated for 16 hrs followed by irradiated with 100 J/cm2 400 to 700 nanometer visible light for 40 mins | Homo sapiens | 6 | ALA4699461 | cell-based format | Scientific Literature | |
4. | ALA4701321 | Functional | Phototoxicity against human SK-MEL-28 cells assessed as reduction in cell viability preincubated for 16 hrs followed by irradiated with 100 J/cm2 625 nanometer red light for 60 mins and measured after 48 hrs by alamar blue assay | Homo sapiens | 6 | ALA4699461 | cell-based format | Scientific Literature | |
5. | ALA4701322 | Unassigned | Phototherapeutic index, ratio of EC50 for cytotoxicity against human SK-MEL-28 cells in dark condition to EC50 for phototoxicity against human SK-MEL-28 cells preincubated for 16 hrs followed by irradiated with 100 J/cm2 625 nanometer red light for 60 mins | Homo sapiens | 6 | ALA4699461 | cell-based format | Scientific Literature | |
6. | ALA4723924 | Binding | Inhibition of human sGC expressed in HUVEC cells assessed as reduction in GMP level incubated for 24 hrs in presence of NPS by ELISA | Homo sapiens | 6 | ALA4715872 | cell-based format | Scientific Literature | |
7. | ALA4723926 | Binding | Inhibition of human sGC expressed in HUVEC cells assessed as reduction in GMP level incubated for 2 hrs by ELISA | Homo sapiens | 2 | ALA4715872 | cell-based format | Scientific Literature | |
8. | ALA4723927 | Binding | Inhibition of bovine lung sGC assessed as reduction in GMP level incubated for 2 hrs in presence of NPS by ELISA | Bos taurus | 6 | ALA4715872 | tissue-based format | Scientific Literature | |
9. | ALA4723930 | Binding | Selectivity ratio of IC50 for inhibition of human sGC expressed in HUVEC cells assessed as reduction in GMP level incubated for 2 hrs to human sGC expressed in HUVEC cells assessed as reduction in GMP level incubated for 2 hrs in presence of NPS | Homo sapiens | 2 | ALA4715872 | cell-based format | Scientific Literature | |
10. | ALA4723933 | Binding | Inhibition of human sGC expressed in HUVEC cells assessed as reduction in GMP level at 2 uM in presence of NPS by ELISA relative to control | Homo sapiens | 2 | ALA4715872 | cell-based format | Scientific Literature | |
11. | ALA4723934 | Binding | Selectivity ratio of inhibition of human sGC expressed in HUVEC cells assessed as reduction in GMP level at 2 uM in presence of NPS to inhibition of human sGC expressed in HUVEC cells assessed as reduction in GMP level at 2 uM in presence of NPS/BAY-412272 | Homo sapiens | 2 | ALA4715872 | cell-based format | Scientific Literature | |
12. | ALA4723935 | Binding | Selectivity ratio of inhibition of human sGC expressed in HUVEC cells assessed as reduction in GMP level at 20 uM in presence of NPS to inhibition of human sGC expressed in HUVEC cells assessed as reduction in GMP level at 20 uM in presence of NPS/BAY-412272 | Homo sapiens | 1 | ALA4715872 | cell-based format | Scientific Literature | |
13. | ALA4723940 | Binding | Inhibition of bovine lung sGC assessed as reduction in GMP level incubated for 2 to 12 hrs in presence of NPS by ELISA | Bos taurus | 6 | ALA4715872 | tissue-based format | Scientific Literature | |
14. | ALA4723941 | Functional | Inhibition of angiogenesis in HEPC-CB1 cells assessed as decrease in total length of pseudovessels at 10 uM after 13 hrs by fluorescence inverted microscopic analysis | Homo sapiens | 2 | ALA4715872 | cell-based format | Scientific Literature | |
15. | ALA4723942 | Functional | Inhibition of angiogenesis in HEPC-CB1 cells assessed as decrease in number of closed structures at 10 uM after 13 hrs by fluorescence inverted microscopic analysis | Homo sapiens | 2 | ALA4715872 | cell-based format | Scientific Literature | |
16. | ALA4723943 | Functional | Inhibition of angiogenesis in HEPC-CB1 cells assessed as decrease in pseudovessels at 10 uM after 13 hrs by fluorescence inverted microscopic analysis | Homo sapiens | 2 | ALA4715872 | cell-based format | Scientific Literature |