| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4670053 | F | Induction of immune response mediated antitumor activity in mouse B16F10 cells xenografted in C57/BL mouse assessed as reduction in tumor weight at 40 mg/kg, ip administered every other day from day 6 post implantation measured every 2 days relative to control | Mus musculus | 1 | ALA4665770 | organism-based format | Scientific Literature | |
| 2. | ALA4670054 | A | Induction of apoptosis in human PBMC cells assessed as activated caspase-3 at 20 uM incubated for 24 hrs by GrennNuc caspase-3 substrate based assay | Homo sapiens | 1 | ALA4665770 | cell-based format | Scientific Literature | |
| 3. | ALA4670055 | F | Induction of immune response mediated antitumor activity in mouse B16F10 cells xenografted in C57/BL mouse assessed as change in ratio of CD8+/CD3+ cells at 40 mg/kg, ip administered every other day from day 6 post implantation by flow cytometry | Mus musculus | 1 | ALA4665770 | organism-based format | Scientific Literature | |
| 4. | ALA4670056 | F | Induction of immune response mediated antitumor activity in mouse B16F10 cells xenografted in C57/BL mouse assessed as change in ratio of CD3+/CD45+ cells at 40 mg/kg, ip administered every other day from day 6 post implantation by flow cytometry | Mus musculus | 1 | ALA4665770 | organism-based format | Scientific Literature | |
| 5. | ALA4670057 | F | Induction of immune response mediated antitumor activity in mouse B16F10 cells xenografted in C57/BL mouse assessed as infiltration of CD8 cells at 40 mg/kg, ip administered every other day from day 6 post implantation by flow cytometry (Rvb = 26.9 %) | Mus musculus | 1 | ALA4665770 | organism-based format | Scientific Literature | |
| 6. | ALA4670058 | F | Induction of immune response mediated antitumor activity in mouse B16F10 cells xenografted in C57/BL mouse assessed as infiltration of CD3 cells at 40 mg/kg, ip administered every other day from day 6 post implantation by flow cytometry (Rvb = 1.45 %) | Mus musculus | 1 | ALA4665770 | organism-based format | Scientific Literature | |
| 7. | ALA4670059 | F | Induction of immune response mediated antitumor activity in mouse B16F10 cells xenografted in C57/BL mouse assessed as infiltration of CD45 cells at 40 mg/kg, ip administered every other day from day 6 post implantation by flow cytometry (Rvb = 1.81 %) | Mus musculus | 1 | ALA4665770 | organism-based format | Scientific Literature | |
| 8. | ALA4670060 | F | Induction of immune response mediated antitumor activity in mouse B16F10 cells xenografted in C57/BL mouse coadministered with anti-CD8 antibody assessed as suppression of tumor growth at 40 mg/kg, ip administered every other day from day 6 post implantation measured every 2 days | Mus musculus | 1 | ALA4665770 | organism-based format | Scientific Literature | |
| 9. | ALA4670061 | F | Induction of immune response mediated antitumor activity in mouse B16F10 cells xenografted in C57/BL mouse assessed as reduction in tumor volume at 40 mg/kg, ip administered every other day from day 6 post implantation measured every 2 days relative to control | Mus musculus | 1 | ALA4665770 | organism-based format | Scientific Literature | |
| 10. | ALA4670062 | T | Toxicity in mouse B16F10 cells xenografted C57/BL mouse assessed as change in body weight at 40 mg/kg, ip administered every other day from day 6 post implantation measured every 2 days | Mus musculus | 1 | ALA4665770 | organism-based format | Scientific Literature | |
| 11. | ALA4670063 | F | Induction of immune response mediated antitumor activity in mouse MC38 cells xenografted in C57/BL mouse assessed as tumor growth inhibition at 40 mg/kg, ip administered every other day from day 6 post implantation measured every 2 days | Mus musculus | 2 | ALA4665770 | organism-based format | Scientific Literature | |
| 12. | ALA4670064 | T | Toxicity in mouse MC38 cells xenografted C57/BL mouse assessed as change in body weight at 40 mg/kg, ip administered every other day from day 6 post implantation measured every 2 days | Mus musculus | 2 | ALA4665770 | organism-based format | Scientific Literature | |
| 13. | ALA4670065 | F | Immunomodulatory activity in mouse MC38 cells xenografted in C57/BL mouse assessed as increase in infiltration of CD3-positive T cells at 40 mg/kg, ip administered every other day from day 6 post implantation by DAPI staining based immunofluorescence microscopy | Mus musculus | 2 | ALA4665770 | organism-based format | Scientific Literature | |
| 14. | ALA4670066 | F | Immunomodulatory activity in mouse MC38 cells xenografted in C57/BL mouse assessed as increase in perforin at 40 mg/kg, ip administered every other day from day 6 post implantation by hematoxylin staining based immunohistochemical analysis | Mus musculus | 2 | ALA4665770 | organism-based format | Scientific Literature | |
| 15. | ALA4670067 | F | Immunomodulatory activity in mouse MC38 cells xenografted in C57/BL mouse assessed as increase in granzyme B at 40 mg/kg, ip administered every other day from day 6 post implantation by hematoxylin staining based immunohistochemical analysis | Mus musculus | 2 | ALA4665770 | organism-based format | Scientific Literature | |
| 16. | ALA4670068 | F | Immunomodulatory activity in mouse MC38 cells xenografted in C57/BL mouse assessed as increase in infiltration of CD8-positive T cells at 40 mg/kg, ip administered every other day from day 6 post implantation by DAPI staining based immunofluorescence microscopy | Mus musculus | 2 | ALA4665770 | organism-based format | Scientific Literature | |
| 17. | ALA4670069 | F | Immunomodulatory activity in human MDA-MB-231 cells cocultured with human PBMC assessed as induction of PBMC recruitment to MDA-MB-231 cells by measuring increase in activated caspase-3 at 20 uM incubated for 24 hrs by GrennNuc caspase-3 substrate based assay | Homo sapiens | 2 | ALA4665770 | cell-based format | Scientific Literature | |
| 18. | ALA4670070 | A | Induction of apoptosis in human MDA-MB-231 cells assessed as activated caspase-3 at 20 uM incubated for 24 hrs by GrennNuc caspase-3 substrate based assay | Homo sapiens | 1 | ALA4665770 | cell-based format | Scientific Literature | |
| 19. | ALA4670071 | F | Immunomodulatory activity in human MDA-MB-231 cocultured with PMBC assessed as induction of PBMC recruitment to MDA-MB-231 cells by measuring increase in cell cluster at 20 uM incubated for 12 to 48 hrs by EVOS FL digital microscopic analysis | Homo sapiens | 1 | ALA4665770 | cell-based format | Scientific Literature | |
| 20. | ALA4670072 | F | Immunomodulatory activity in human CFDA SE-labelled MDA-MB-231 cells cocultured with PMBC assessed as induction of PBMC recruitment to MDA-MB-231 cells by measuring early apoptotic cells at 20 uM incubated for 48 hrs by propidium iodide staining based flow cytometry analysis (Rvb = 0 %) | Homo sapiens | 2 | ALA4665770 | cell-based format | Scientific Literature |
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