# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4727374 | Binding | Inhibition of beta-1,3-glucan synthase in Candida albicans MY1055 microsomal membrane using UDP-[3H]-glucose as substrate incubated for 2 hrs in presence of UTP by radioactivity-based assay | Candida albicans | 30 | ALA4725308 | cell membrane format | Scientific Literature | |
2. | ALA4727375 | Functional | Antifungal activity against Candida albicans MY1055 assessed as fungal growth inhibition measured after 24 hrs by liquid microdilution method | Candida albicans | 30 | ALA4725308 | organism-based format | Scientific Literature | |
3. | ALA4727376 | Functional | Antifungal activity against Aspergillus fumigatus MF5668 assessed as fungal growth inhibition measured after 24 hrs by liquid microdilution method | Aspergillus fumigatus | 30 | ALA4725308 | organism-based format | Scientific Literature | |
4. | ALA4727377 | ADME | AUC in po dosed mouse | Mus musculus | 16 | ALA4725308 | organism-based format | Scientific Literature | |
5. | ALA4727378 | ADME | Oral bioavailability in mouse | Mus musculus | 16 | ALA4725308 | organism-based format | Scientific Literature | |
6. | ALA4727379 | Functional | Antifungal activity against Candida albicans MY1055 infected in DBA/2 mouse model assessed as log change in colony forming units in kidney at 6.5 mg/kg, po bid for 2 days and measured after 4 days by TOKA | Candida albicans | 19 | ALA4725308 | organism-based format | Scientific Literature | |
7. | ALA4727380 | Functional | Antifungal activity against Candida albicans MY1055 infected in DBA mouse model assessed as log change in colony forming units in kidney at 12.5 mg/kg, po bid for 2 days and measured after 4 days by TOKA | Candida albicans | 19 | ALA4725308 | organism-based format | Scientific Literature | |
8. | ALA4727381 | Functional | Antifungal activity against Candida albicans MY1055 infected in DBA/2 mouse model assessed as log change in colony forming units in kidney at 25 mg/kg, po bid for 2 days and measured after 4 days by TOKA | Candida albicans | 19 | ALA4725308 | organism-based format | Scientific Literature | |
9. | ALA4727382 | Functional | Antifungal activity against Candida glabrata MY1381 assessed as fungal growth inhibition | Nakaseomyces glabratus | 1 | ALA4725308 | organism-based format | Scientific Literature | |
10. | ALA4727383 | Functional | Antifungal activity against Candida krusei ATCC 6258 assessed as fungal growth inhibition | Pichia kudriavzevii | 1 | ALA4725308 | organism-based format | Scientific Literature | |
11. | ALA4727384 | Functional | Antifungal activity against Candida tropicalis MY1012 assessed as fungal growth inhibition | Candida tropicalis | 1 | ALA4725308 | organism-based format | Scientific Literature | |
12. | ALA4727385 | Functional | Antifungal activity against Clavispora lusitaniae MY1396 assessed as fungal growth inhibition | Clavispora lusitaniae | 1 | ALA4725308 | organism-based format | Scientific Literature | |
13. | ALA4727386 | Functional | Antifungal activity against Candida parapsilosis ATCC 22019 assessed as fungal growth inhibition | Candida parapsilosis | 1 | ALA4725308 | organism-based format | Scientific Literature | |
14. | ALA4727387 | ADME | Clearance in mouse | Mus musculus | 1 | ALA4725308 | organism-based format | Scientific Literature | |
15. | ALA4727388 | ADME | Half lie in mouse | Mus musculus | 1 | ALA4725308 | organism-based format | Scientific Literature | |
16. | ALA4727389 | ADME | Clearance in rat | Rattus norvegicus | 1 | ALA4725308 | assay format | Scientific Literature | |
17. | ALA4727390 | ADME | Half life in rat | Rattus norvegicus | 1 | ALA4725308 | assay format | Scientific Literature | |
18. | ALA4727391 | ADME | AUC in po dosed rat | Rattus norvegicus | 1 | ALA4725308 | organism-based format | Scientific Literature | |
19. | ALA4727392 | ADME | Oral bioavailability in rat | Rattus norvegicus | 1 | ALA4725308 | organism-based format | Scientific Literature | |
20. | ALA4727393 | ADME | Clearance in dog | Canis lupus familiaris | 1 | ALA4725308 | assay format | Scientific Literature |