# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4728137 | A | Intrinsic clearance in CD-1 mouse liver microsomes | Mus musculus | 1 | ALA4725343 | microsome format | Scientific Literature | |
2. | ALA4728138 | A | Induction of CYP3A4 (unknown origin) at 10 uM incubated for 3 hrs by LC/MS/MS analysis relative to control | Homo sapiens | 1 | ALA4725343 | single protein format | Scientific Literature | |
3. | ALA4728139 | A | Intrinsic clearance in Han Wistar rat hepatocytes assessed per million cells at 1 uM by LC-MS/MS analysis | Rattus norvegicus | 66 | ALA4725343 | cell-based format | Scientific Literature | |
4. | ALA4728140 | F | Growth inhibition of Trypanosoma brucei brucei incubated for 72 hrs by resazurin dye based assay | Trypanosoma brucei brucei | 67 | ALA4725343 | organism-based format | Scientific Literature | |
5. | ALA4728141 | A | Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by resazurin dye based fluorescence analysis | Homo sapiens | 2 | ALA4725343 | cell-based format | Scientific Literature | |
6. | ALA4728142 | T | Selectivity index, difference between pEC50 for Trypanosoma brucei brucei to pTC50 for human MRC5 cells | 64 | ALA4725343 | assay format | Scientific Literature | ||
7. | ALA4728143 | P | Thermodynamic solubility of the compound in aqueous phosphate buffer at pH 7.4 measured after 20 to 24 hrs by LC/MS/MS analysis | 67 | ALA4725343 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA4728144 | P | Distribution coefficient between octanol and aqueous buffer, logD of the compound in pH 7.4 buffer by UPLC-MS-based shake flask method | 2 | ALA4725343 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA4728145 | A | Fraction unbound in human plasma after 18 hrs by equilibrium dialysis based LC-MS/MS analysis | Homo sapiens | 2 | ALA4725343 | cell-free format | Scientific Literature | |
10. | ALA4728146 | A | Intrinsic clearance in human liver microsomes assessed per mg protein by LC-MS/MS analysis | Homo sapiens | 67 | ALA4725343 | microsome format | Scientific Literature | |
11. | ALA4728147 | B | Inhibition of N-terminal 8His-fused Trypanosoma brucei MAPK6 expressed in Escherichia coli incubated for 30 mins by ADP-Glo luminescence assay | Trypanosoma brucei | 2 | ALA4725343 | assay format | Scientific Literature | |
12. | ALA4728148 | A | Apparent permeability across apical to basolateral side in human Caco2 cells after 2 hrs | Homo sapiens | 1 | ALA4725343 | cell-based format | Scientific Literature | |
13. | ALA4728149 | A | Apparent permeability across basolateral to apical side in human Caco2 cells after 2 hrs | Homo sapiens | 1 | ALA4725343 | cell-based format | Scientific Literature | |
14. | ALA4728150 | A | Efflux ratio of apparent permeability in human Caco2 cells after 2 hrs | Homo sapiens | 1 | ALA4725343 | cell-based format | Scientific Literature | |
15. | ALA4728151 | A | Apparent permeability across apical to basolateral side in human Caco2 cells assessed as drug recovery after 2 hrs | Homo sapiens | 1 | ALA4725343 | cell-based format | Scientific Literature | |
16. | ALA4728152 | A | Apparent permeability across basolateral to apical side in human Caco2 cells assessed as drug recovery after 2 hrs | Homo sapiens | 1 | ALA4725343 | cell-based format | Scientific Literature | |
17. | ALA4728153 | A | Stability in CD-1 mouse plasma assessed as compound remaining at 2 uM after 60 mins by LC-MS analysis | Mus musculus | 1 | ALA4725343 | cell-free format | Scientific Literature | |
18. | ALA4728154 | A | Inhibition of CYP3A4 (unknown origin) at 10 uM incubated for 30 mins by LC/MS/MS analysis relative to control | Homo sapiens | 1 | ALA4725343 | single protein format | Scientific Literature | |
19. | ALA4728155 | A | Cmax in NMRI mouse at 10 mg/kg, ip measured up to 6 hrs on day 1 by LC-MS/MS analysis | Mus musculus | 1 | ALA4725343 | organism-based format | Scientific Literature | |
20. | ALA4728156 | A | Cmax in ABT-treated NMRI mouse at 30 mg/kg, ip measured up to 6 hrs on day 1 by LC-MS/MS analysis | Mus musculus | 1 | ALA4725343 | organism-based format | Scientific Literature |