| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4737518 | F | Agonist activity at RXFP1 endogenously expressed in human OVCAR-5 cells assessed as increase in IBMX-induced cAMP accumulation pretreated with IBMX for 40 mins followed by compound addition and measured after 30 mins by HTRF assay | Homo sapiens | 42 | cell-based format | Scientific Literature | ||
| 2. | ALA4737519 | F | Agonist activity at RXFP1 endogenously expressed in human OVCAR-5 cells assessed as increase in IBMX-induced cAMP accumulation pretreated with IBMX for 40 mins followed by compound addition and measured after 30 mins by HTRF assay relative to relaxin | Homo sapiens | 42 | cell-based format | Scientific Literature | ||
| 3. | ALA4737525 | B | Agonist activity at rat RXFP1 expressed in human HEK296 cells assessed as increase in IBMX-induced cAMP accumulation pretreated with IBMX for 40 mins followed by compound addition and measured after 30 mins by HTRF assay | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
| 4. | ALA4737526 | B | Agonist activity at rat RXFP1 expressed in human HEK296 cells assessed as increase in IBMX-induced cAMP accumulation pretreated with IBMX for 40 mins followed by compound addition and measured after 30 mins by HTRF assay relative to control | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA4737527 | A | Half life in Sprague-Dawley rat at 1 mg/kg, iv measured upto 72 hrs by LC-HRMS analysis | Rattus norvegicus | 13 | organism-based format | Scientific Literature | ||
| 6. | ALA4737528 | F | Agonist activity at RXFP1 endogenously expressed in human OVCAR-5 cells assessed as increase in IBMX-induced cAMP accumulation pretreated with IBMX for 40 mins followed by compound addition and measured after 30 mins in presence of 2 % HSA by HTRF assay | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 7. | ALA4737529 | F | Agonist activity at RXFP1 endogenously expressed in human OVCAR-5 cells assessed as increase in IBMX-induced cAMP accumulation pretreated with IBMX for 40 mins followed by compound addition and measured after 30 mins in presence of 2 % HSA by HTRF assay relative to control | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 8. | ALA4737530 | B | Selectivity ratio of EC50 for agonist activity at RXFP1 endogenously expressed in human OVCAR-5 cells in presence of 2 % HSA to EC50 for agonist activity at RXFP1 endogenously expressed in human OVCAR-5 cells in absence of HSA | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 9. | ALA4737532 | B | Selectivity index, ratio of EC50 for agonist activity at rat RXFP1 expressed in human HEK296 cells in presence of RSA by HTRF assay to EC50 for EC50 for agonist activity at rat RXFP1 expressed in human HEK296 cells in absence of RSA by HTRF assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4737533 | A | Positive chronotropic activity in pithed Sprague-Dawley rat assessed as increase in heart rate at 20 to 1000 mg/kg, iv administered as bolus dose measured after 60 mins post dose | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 11. | ALA4737534 | A | Positive chronotropic activity in pithed Sprague-Dawley rat assessed as increase in heart rate at 1000 mg/kg, iv administered as bolus dose measured after 60 mins post dose | Rattus norvegicus | 3 | organism-based format | Scientific Literature |
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