| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4775686 | B | Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysis | Homo sapiens | 11 | ALA4765484 | assay format | Scientific Literature | |
| 2. | ALA4775687 | B | Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) assessed as binding constant (Kon) by SPR analysis | Homo sapiens | 11 | ALA4765484 | assay format | Scientific Literature | |
| 3. | ALA4775688 | B | Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) assessed as binding constant (Koff) by SPR analysis | Homo sapiens | 11 | ALA4765484 | assay format | Scientific Literature | |
| 4. | ALA4775692 | B | Inhibition of probe-5 binding to human TNFalpha (77 to 233 residues) at 1 nM by fluorescence polarization assay | Homo sapiens | 11 | ALA4765484 | single protein format | Scientific Literature | |
| 5. | ALA4775693 | B | Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) assessed as binding half life by SPR analysis | Homo sapiens | 3 | ALA4765484 | assay format | Scientific Literature | |
| 6. | ALA4775698 | B | Inhibition of TNFalpha in mouse L929 cells exposed to compound incubated for 1 hr with mouse TNFalpha by luminescence based assay | Mus musculus | 11 | ALA4765484 | cell-based format | Scientific Literature | |
| 7. | ALA4775699 | A | Half life in CD1 mouse at 1 mg/kg, iv after 24 hrs by HPLC-MS/MS analysis | Mus musculus | 3 | ALA4765484 | organism-based format | Scientific Literature | |
| 8. | ALA4775700 | A | Volume of distribution at steady state in CD1 mouse at 1 mg/kg, iv after 24 hrs by HPLC-MS/MS analysis | Mus musculus | 3 | ALA4765484 | organism-based format | Scientific Literature | |
| 9. | ALA4775701 | A | AUC in CD1 mouse at 1 mg/kg, iv after 24 hrs by HPLC-MS/MS analysis | Mus musculus | 3 | ALA4765484 | organism-based format | Scientific Literature | |
| 10. | ALA4775702 | A | Blood clearance in CD1 mouse at 1 mg/kg, iv after 24 hrs by HPLC-MS/MS analysis | Mus musculus | 3 | ALA4765484 | organism-based format | Scientific Literature | |
| 11. | ALA4775703 | A | Unbound clearance in CD1 mouse at 1 mg/kg, iv after 24 hrs by HPLC-MS/MS analysis | Mus musculus | 3 | ALA4765484 | organism-based format | Scientific Literature | |
| 12. | ALA4775704 | A | Half life in CD1 mouse at 1 mg/kg, po after 24 hrs by HPLC-MS/MS analysis | Mus musculus | 3 | ALA4765484 | organism-based format | Scientific Literature | |
| 13. | ALA4775705 | A | Cmax in CD1 mouse at 1 mg/kg, po after 24 hrs by HPLC-MS/MS analysis | Mus musculus | 3 | ALA4765484 | organism-based format | Scientific Literature | |
| 14. | ALA4775706 | A | Tmax in CD1 mouse at 1 mg/kg, po after 24 hrs by HPLC-MS/MS analysis | Mus musculus | 3 | ALA4765484 | organism-based format | Scientific Literature | |
| 15. | ALA4775707 | A | AUC in CD1 mouse at 1 mg/kg, po after 24 hrs by HPLC-MS/MS analysis | Mus musculus | 3 | ALA4765484 | organism-based format | Scientific Literature | |
| 16. | ALA4775708 | A | Unbound AUC in CD1 mouse at 1 mg/kg, po after 24 hrs by HPLC-MS/MS analysis | Mus musculus | 3 | ALA4765484 | organism-based format | Scientific Literature | |
| 17. | ALA4775709 | A | Oral bioavailability in CD1 mouse at 1 mg/kg after 24 hrs by HPLC-MS/MS analysis | Mus musculus | 3 | ALA4765484 | organism-based format | Scientific Literature | |
| 18. | ALA4775710 | F | Antiarthritic activity in DBA/J mouse model of CFA and glucose-6-phosphate isomerase-induced arthritis model assessed as inhibition of paw swelling at 30 to 100 mg/kg, po BID beginning 1 hr prior to GPI immunization and measured on days 13, 15, and 17 after GPI immunization | Mus musculus | 1 | ALA4765484 | organism-based format | Scientific Literature | |
| 19. | ALA4775711 | A | Drug uptake in DBA/J mouse model of CFA and glucose-6-phosphate isomerase-induced arthritis model at 10 to 100 mg/kg, po BID beginning 1 hr prior to GPI immunization and measured up to day 17 after GPI immunization by HPLC-MS/MS analysis | Mus musculus | 1 | ALA4765484 | organism-based format | Scientific Literature | |
| 20. | ALA4775712 | A | Cmax in DBA/J mouse model of CFA and glucose-6-phosphate isomerase-induced arthritis model at 10 mg/kg, po BID beginning 1 hr prior to GPI immunization and measured up to day 17 after GPI immunization by HPLC-MS/MS analysis | Mus musculus | 1 | ALA4765484 | organism-based format | Scientific Literature |
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