# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4706776 | ADME | Inhibition of CYP2C19 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysis | Homo sapiens | 5 | ALA4706474 | microsome format | Scientific Literature | |
2. | ALA4706777 | ADME | Inhibition of CYP2C9 in human liver microsomes using isoform-specific probe substrates in presence of NADPH-generating system by LC-MS analysis | Homo sapiens | 5 | ALA4706474 | microsome format | Scientific Literature | |
3. | ALA4706778 | ADME | Cmax in Sprague-Dawley rat at 21.3 mg/kg, po measured over 24 hrs by LC-MS analysis | Rattus norvegicus | 1 | ALA4706474 | organism-based format | Scientific Literature | |
4. | ALA4706780 | Binding | Inhibition of N-terminal His6-tagged Plasmodium falciparum DHODH expressed in Escherichia coli BL21 using L-DHO as substrate and CoQ as co-substrate by DCIP dye based spectrophotometric assay | Plasmodium falciparum | 28 | ALA4706474 | assay format | Scientific Literature | |
5. | ALA4706781 | Binding | Inhibition of N-terminal His6-tagged Plasmodium vivax DHODH expressed in Escherichia coli BL21 using L-DHO as substrate and CoQ as co-substrate by DCIP dye based spectrophotometric assay | Plasmodium vivax | 28 | ALA4706474 | assay format | Scientific Literature | |
6. | ALA4706782 | ADME | Inhibition of N-terminal His6-tagged human DHODH expressed in Escherichia coli BL21 using L-DHO as substrate and CoQ as co-substrate by DCIP dye based spectrophotometric assay | Homo sapiens | 28 | ALA4706474 | assay format | Scientific Literature | |
7. | ALA4706783 | Functional | Antiplasmodial activity against Plasmodium falciparum 3D7 infected in RBC assessed as reduction in parasitemia incubated for 72 hrs by SYBR green dye-based assay | Plasmodium falciparum | 28 | ALA4706474 | organism-based format | Scientific Literature | |
8. | ALA4706784 | Binding | Inhibition of N-terminal His6-tagged rat DHODH expressed in Escherichia coli BL21 expressed in Escherichia coli BL21 using L-DHO as substrate and CoQ as co-substrate by DCIP dye based spectrophotometric assay | Rattus norvegicus | 6 | ALA4706474 | assay format | Scientific Literature | |
9. | ALA4706785 | Binding | Inhibition of N-terminal His6-tagged mouse DHODH expressed in Escherichia coli BL21 using L-DHO as substrate and CoQ as co-substrate by DCIP dye based spectrophotometric assay | Mus musculus | 6 | ALA4706474 | assay format | Scientific Literature | |
10. | ALA4706786 | Binding | Inhibition of N-terminal His6-tagged dog DHODH expressed in Escherichia coli BL21 using L-DHO as substrate and CoQ as co-substrate by DCIP dye based spectrophotometric assay | Canis lupus familiaris | 6 | ALA4706474 | assay format | Scientific Literature | |
11. | ALA4706787 | Physicochemical | Lipophilicity, logD of the compound at pH 7.4 | 18 | ALA4706474 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA4706788 | Physicochemical | Kinetic solubility of compound in phosphate buffer at pH 6.5 measured after 30 mins by HPLC-UV based analysis | 18 | ALA4706474 | small-molecule physicochemical format | Scientific Literature | ||
13. | ALA4706789 | ADME | Protein binding in human plasma assessed as bound fraction by LC-MS analysis based ultracentrifugation assay | Homo sapiens | 6 | ALA4706474 | cell-free format | Scientific Literature | |
14. | ALA4706790 | ADME | Protein binding in rat plasma assessed as bound fraction by LC-MS analysis based ultracentrifugation assay | Rattus norvegicus | 6 | ALA4706474 | cell-free format | Scientific Literature | |
15. | ALA4706791 | ADME | Protein binding in mouse plasma assessed as bound fraction by LC-MS analysis based ultracentrifugation assay | Mus musculus | 5 | ALA4706474 | cell-free format | Scientific Literature | |
16. | ALA4706792 | ADME | Ratio of drug level in blood to plasma in rat | Rattus norvegicus | 6 | ALA4706474 | cell-free format | Scientific Literature | |
17. | ALA4706793 | ADME | Intrinsic clearance in human pooled liver microsomes assessed per mg protein at 1 uM by LC-MS analysis | Homo sapiens | 18 | ALA4706474 | microsome format | Scientific Literature | |
18. | ALA4706794 | ADME | Intrinsic clearance in rat liver microsomes assessed per mg protein at 1 uM by LC-MS analysis | Rattus norvegicus | 17 | ALA4706474 | microsome format | Scientific Literature | |
19. | ALA4706795 | ADME | Intrinsic clearance in mouse liver microsomes at 1 uM by LC-MS analysis | Mus musculus | 18 | ALA4706474 | microsome format | Scientific Literature | |
20. | ALA4706796 | Binding | Inhibition of human ERG by patch clamp electrophysiology assay | Homo sapiens | 18 | ALA4706474 | assay format | Scientific Literature |