| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4775170 | F | Antagonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 2. | ALA4775171 | F | Antagonist activity at human MC4R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as reduction in alpha-MSH-induced cAMP accumulation by cAMP split-luciferase reporter gene assay | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 3. | ALA4775172 | B | Selectivity index, ratio of IC50 for antagonist activity at human MC4R expressed in HEK293 cells to IC50 for antagonist activity at human MC3R expressed in HEK293 cells | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 4. | ALA4775179 | B | Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC3R expressed in HEK293 cell membranes incubated for 120 mins | Homo sapiens | 17 | cell membrane format | Scientific Literature | ||
| 5. | ALA4775180 | B | Displacement of [125I]-[NIe,DPhe7]-alpha-MSH from human MC4R expressed in HEK293 cell membranes incubated for 120 mins | Homo sapiens | 17 | cell membrane format | Scientific Literature | ||
| 6. | ALA4775181 | B | Selectivity index, ratio of Ki for human MC3R expressed in HEK293 cell membranes to Ki for human MC4R expressed in HEK293 cell membranes | Homo sapiens | 17 | cell-based format | Scientific Literature |
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