| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4731698 | B | Inhibition of full length C-terminal His/FLAG-tagged human HDAC1 expressed in baculovirus expression system using ZMAL as substrate incubated for 90 mins by fluorescence assay | Homo sapiens | 9 | assay format | Scientific Literature | ||
| 2. | ALA4731699 | B | Inhibition of full length N-terminal GST-tagged human HDAC6 expressed in baculovirus expression system using ZMAL as substrate incubated for 90 mins by fluorescence assay | Homo sapiens | 9 | assay format | Scientific Literature | ||
| 3. | ALA4731700 | B | Selectivity ratio of IC50 for full length C-terminal His/FLAG-tagged human HDAC1 expressed in baculovirus expression system to IC50 full length N-terminal GST-tagged human HDAC6 expressed in baculovirus expression system | Homo sapiens | 12 | assay format | Scientific Literature | ||
| 4. | ALA4731701 | B | Inhibition of human recombinant HDAC8 expressed in Escherichia coli using Fluor de Lys substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluorescence assay | 4 | assay format | Scientific Literature | |||
| 5. | ALA4731704 | B | Inhibition of HDAC6 in human MEC1 cells assessed as reduction in STAT3 phosphorylation measured after 30 hrs by immunoblot assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4731705 | A | Cytotoxicity against mouse NIH3T3 cells assessed as reduction in cell viability measured after 24 hrs by neutral red uptake assay | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 7. | ALA4731707 | F | Antiproliferative activity against human OE33 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 8. | ALA4731708 | F | Antiproliferative activity against human Ca9-22 cells assessed as reduction in cell viability measured after 48 hrs by alamar blue dye based spectrofluorometry | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 9. | ALA4731709 | F | Antiproliferative activity against human TR-146 cells assessed as reduction in cell viability measured after 48 hrs by alamar blue dye based spectrofluorometry | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 10. | ALA4731710 | F | Antiproliferative activity against human U266B cells assessed as reduction in cell viability measured after 24 to 48 hrs by alamar blue dye based fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA4731715 | F | Cell cycle arrest in human U-937 cells assessed as increase in accumulation at pre-G1 phase at 10 uM measured after 48 hrs by propidium iodide staining based flow cytometry | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4731717 | F | Cell cycle arrest in human NB-4 cells at 5 to 10 uM measured after 48 hrs by propidium iodide staining based flow cytometry | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4731718 | B | Inhibition of HDAC6 in human NB-4 cells assessed as increase in tubulin acetylation at 10 uM measured after 24 to 48 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 14. | ALA4731719 | A | Inhibition of HDAC in human NB-4 cells assessed as effect on histone acetylation at 10 uM measured after 24 to 48 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA4731720 | F | Induction of apoptosis in human NB-4 cells assessed as increase in cleaved PARP expression at 10 uM measured after 24 to 48 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 16. | ALA4731721 | F | Induction of apoptosis in human U266B cells at 25 to 50 uM measured after 48 hrs by Annexin-V/propidium iodide staining based flow cytometry | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4731722 | B | Inhibition of HDAC6 in human U-266 cells assessed as reduction in STAT3 phosphorylation measured after 4 to 48 hrs by immunoblot assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4731728 | T | Mutagenicity in Salmonella typhimurium TA100 at 24 to 40 uM measured after 90 mins in absence of S9 fraction by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 2 | assay format | Scientific Literature | ||
| 19. | ALA4731729 | T | Mutagenicity in Salmonella typhimurium TA100 at 24 to 40 uM measured after 90 mins in presence of S9 fraction by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 2 | subcellular format | Scientific Literature |
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