# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4700758 | F | Inhibition of amyloid beta (1 to 42) secretion in human H4 cells overexpressing APP incubated for overnight by HTRF analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
2. | ALA4700762 | F | Reduction in amyloid beta (1 to 42) secretion in brain in triple transgenic LaFerla mouse at 30 mg/kg, po measured after 3 hrs relative to control | Mus musculus | 3 | organism-based format | Scientific Literature | ||
3. | ALA4700763 | A | Ratio of drug level in brain to plasma in triple transgenic LaFerla mouse at 30 mg/kg, po measured after 3 hrs | Mus musculus | 2 | organism-based format | Scientific Literature | ||
4. | ALA4700764 | F | Reduction in amyloid beta (1 to 42) secretion in brain in Harlan Sprague-Dawley rat at 10 mg/kg, po measured after 3 hrs relative to control | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
5. | ALA4700765 | A | Plasma concentration in triple transgenic LaFerla mouse at 30 mg/kg, po measured after 3 hrs | Mus musculus | 1 | organism-based format | Scientific Literature | ||
6. | ALA4700766 | A | Plasma concentration in Harlan Sprague-Dawley rat at 10 mg/kg, po measured after 3 hrs | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
7. | ALA4700767 | A | Stability in human liver microsomes assessed as remaining compound measured after 10 mins by LC-MS/MS analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
8. | ALA4700768 | A | AUC (0 to 24 hrs) in Harlan Sprague-Dawley rat incubated for 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
9. | ALA4700769 | F | Antialzheimer activity in Harlan Sprague-Dawley rat brain assessed as reduction in amyloid beta (1 to 42) AUC relative to control | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
10. | ALA4700770 | F | Antialzheimer activity in cynomolgus monkey brain assessed as reduction in amyloid beta (1 to 42) AUC at 1.3 mg/kg qd relative to control | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
11. | ALA4700771 | F | Antialzheimer activity in Beagle dog brain assessed as reduction in amyloid beta (1 to 42) AUC at 1.3 mg/kg qd relative to control | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
12. | ALA4700772 | A | Oral bioavailability in Sprague-Dawley rat incubated for 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
13. | ALA4700773 | A | Oral bioavailability in cynomolgus monkey incubated for 24 hrs by LC-MS/MS analysis | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
14. | ALA4700774 | A | Oral bioavailability in Beagle dog incubated for 24 hrs by LC-MS/MS analysis | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
15. | ALA4700775 | B | Inhibition of human ERG by patch clamp method | Homo sapiens | 2 | assay format | Scientific Literature | ||
16. | ALA4700776 | T | Cardiotoxicity in rabbit assessed as NOAEL by telemetric analysis | Oryctolagus cuniculus | 1 | assay format | Scientific Literature | ||
17. | ALA4700777 | T | Toxicity in rat assessed as increase in unconjugated bilirubin in plasma at 10 to 100 mg/kg, po administered for 4 days | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
18. | ALA4700778 | A | Inhibition of human UGT1A1 | Homo sapiens | 2 | single protein format | Scientific Literature | ||
19. | ALA4700779 | A | Inhibition of OATP1B1 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
20. | ALA4700780 | T | Toxicity in rat assessed as hepatocellular necrosis at 10 to 100 mg/kg, po administered for 4 days by histological assay | Rattus norvegicus | 1 | organism-based format | Scientific Literature |