| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4721240 | B | Inhibition of wild-type human partial length INSRR (R950 to E1278 residues) expressed in bacterial expression system assessed as residual activity at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4715821 | assay format | Scientific Literature | |
| 2. | ALA4721241 | B | Inhibition of wild-type human partial length IRAK4 (M1 to S460 residues) expressed in mammalian expression system assessed as residual activity at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4715821 | assay format | Scientific Literature | |
| 3. | ALA4721242 | B | Inhibition of wild-type human partial length NDR1 (N33 to E449 residues) expressed in mammalian expression system assessed as residual activity at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4715821 | assay format | Scientific Literature | |
| 4. | ALA4721243 | B | Inhibition of recombinant His6-Tev-LRRK2 (1326 to 2527 residues) (unknown origin) using LRRKtide as substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of ATP by TR-FRET assay | Homo sapiens | 22 | ALA4715821 | single protein format | Scientific Literature | |
| 5. | ALA4721244 | B | Inhibition of recombinant full-length LRRK2 (unknown origin) expressed in SH-SY5Y cells assessed as reduction in Ser935 phosphorylation after 60 mins by Alpha Screen assay | Homo sapiens | 22 | ALA4715821 | cell-based format | Scientific Literature | |
| 6. | ALA4721245 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance | Homo sapiens | 10 | ALA4715821 | microsome format | Scientific Literature | |
| 7. | ALA4721246 | B | Inhibition of DYRK3 (unknown origin) assessed as residual activity at 1 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4715821 | single protein format | Scientific Literature | |
| 8. | ALA4721247 | P | Lipophilicity, logD of compound at pH 7.4 | 12 | ALA4715821 | small-molecule physicochemical format | Scientific Literature | ||
| 9. | ALA4721248 | A | Dose normalized AUC (0 to t) in Han-Wistar rat blood at 10 mg/kg, po measured up to 7 hrs by UPLC-MS/MS analysis | Rattus norvegicus | 1 | ALA4715821 | organism-based format | Scientific Literature | |
| 10. | ALA4721249 | A | Passive permeability of the compound across apical to basolateral side in MDCK2 cells transfected with Bacmam virus containing human BCRP at 3 uM after 90 mins in presence of GF120918 | Canis lupus familiaris | 10 | ALA4715821 | cell-based format | Scientific Literature | |
| 11. | ALA4721250 | P | Solubility of the compound in FaSSIF measured after 4 hrs | 12 | ALA4715821 | small-molecule physicochemical format | Scientific Literature | ||
| 12. | ALA4721251 | A | Permeability ratio across apical side to basolateral side in MDCK2 cells transfected with Bacmam virus containing human BCRP at 3 uM after 90 mins in presence or absence of GF120918 by transwell assay | Canis lupus familiaris | 10 | ALA4715821 | cell-based format | Scientific Literature | |
| 13. | ALA4721253 | A | Dose normalized AUC (0 to t) in Han-Wistar rat brain at 10 mg/kg, po measured up to 7 hrs by UPLC-MS/MS analysis | Rattus norvegicus | 1 | ALA4715821 | organism-based format | Scientific Literature | |
| 14. | ALA4721255 | A | Ratio of total drug concentration in brain to blood in Han-Wistar rat at 10 mg/kg, po | Rattus norvegicus | 1 | ALA4715821 | organism-based format | Scientific Literature | |
| 15. | ALA4721257 | A | Unbound fraction in Han-Wistar rat brain at 10 mg/kg, po | Rattus norvegicus | 1 | ALA4715821 | organism-based format | Scientific Literature | |
| 16. | ALA4721259 | B | Inhibition of LRRK2 in human AHE cells assessed as reduction in Ser935 phosphorylation | Homo sapiens | 1 | ALA4715821 | cell-based format | Scientific Literature | |
| 17. | ALA4721260 | B | Inhibition of LRRK2 G2019S mutant in human ANK cells assessed as reduction in Ser935 phosphorylation | Homo sapiens | 1 | ALA4715821 | cell-based format | Scientific Literature | |
| 18. | ALA4721261 | A | Unbound fraction in rat blood | Rattus norvegicus | 1 | ALA4715821 | tissue-based format | Scientific Literature | |
| 19. | ALA4721262 | A | Unbound fraction in mouse blood | Mus musculus | 1 | ALA4715821 | tissue-based format | Scientific Literature | |
| 20. | ALA4721263 | A | Unbound fraction in mouse brain | Mus musculus | 1 | ALA4715821 | tissue-based format | Scientific Literature |
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