# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4729229 | B | Inhibition of human PDE5A1 (535-860 residues) expressed in Escherichia coli BL21 incubated for 15 mins using [3H]-cGMP as substrate by liquid scintillation counting method | Homo sapiens | 14 | ALA4725363 | assay format | Scientific Literature | |
2. | ALA4729230 | A | Inhibition of human PDE6C (2-854 residues) expressed in Sf9 cells incubated for 15 mins using [3H]-cGMP as substrate by liquid scintillation counting method | Homo sapiens | 5 | ALA4725363 | cell-based format | Scientific Literature | |
3. | ALA4729231 | B | Selectivity index, ratio of IC50 for human PDE6C to IC50 for human PDE5A1 | Homo sapiens | 5 | ALA4725363 | assay format | Scientific Literature | |
4. | ALA4729232 | B | Inhibition of Top2 (unknown origin) mediated supercoiled DNA relaxation at 100 uM | Homo sapiens | 2 | ALA4725363 | single protein format | Scientific Literature | |
5. | ALA4729233 | B | Inhibition of Top (unknown origin) mediated supercoiled DNA relaxation at 100 uM | Homo sapiens | 2 | ALA4725363 | single protein format | Scientific Literature | |
6. | ALA4729234 | A | Inhibition of human PDE1B (10-487 residues) expressed in Sf9 cells incubated for 15 mins using [3H]-cGMP as substrate by liquid scintillation counting method | Homo sapiens | 2 | ALA4725363 | cell-based format | Scientific Literature | |
7. | ALA4729235 | B | Selectivity index, ratio of IC50 for human PDE1B to IC50 for human PDE5A1 | Homo sapiens | 2 | ALA4725363 | assay format | Scientific Literature | |
8. | ALA4729236 | A | Inhibition of PDE2A catalytic domain (580 to 941 residues) (unknown origin) using 3H-cGMP as substrate after 15 mins by liquid scintillation counting method | Homo sapiens | 2 | ALA4725363 | single protein format | Scientific Literature | |
9. | ALA4729237 | B | Selectivity index, ratio of IC50 for PDE2A (unknown origin) to IC50 for human PDE5A1 | Homo sapiens | 2 | ALA4725363 | assay format | Scientific Literature | |
10. | ALA4729238 | A | Inhibition of PDE3A catalytic domain (679 to 1087 residues) (unknown origin) using 3H-cAMP as substrate after 15 mins by liquid scintillation counting method | Homo sapiens | 2 | ALA4725363 | single protein format | Scientific Literature | |
11. | ALA4729239 | B | Selectivity index, ratio of IC50 for PDE3A (unknown origin) to IC50 for human PDE5A1 | Homo sapiens | 2 | ALA4725363 | assay format | Scientific Literature | |
12. | ALA4729240 | A | Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) using [3H]cAMP as substrate after 15 mins by liquid scintillation counting method | Homo sapiens | 2 | ALA4725363 | single protein format | Scientific Literature | |
13. | ALA4729241 | B | Selectivity index, ratio of IC50 for human PDE4D2 to IC50 for human PDE5A1 | Homo sapiens | 2 | ALA4725363 | assay format | Scientific Literature | |
14. | ALA4729242 | A | Inhibition of PDE7A1 catalytic domain (130 to 482 residues) (unknown origin) using [3H]-cAMP as substrate after 15 mins by liquid scintillation counting method | Homo sapiens | 2 | ALA4725363 | single protein format | Scientific Literature | |
15. | ALA4729243 | B | Selectivity index, ratio of IC50 for PDE7A1 (unknown origin) to IC50 for human PDE5A1 | Homo sapiens | 2 | ALA4725363 | assay format | Scientific Literature | |
16. | ALA4729244 | A | Inhibition of PDE8A1 catalytic domain (480 to 820 residues) (unknown origin) using [3H]-cAMP as substrate after 15 mins by liquid scintillation counting method | Homo sapiens | 2 | ALA4725363 | single protein format | Scientific Literature | |
17. | ALA4729245 | B | Selectivity index, ratio of IC50 for PDE8A1 (unknown origin) to IC50 for human PDE5A1 | Homo sapiens | 2 | ALA4725363 | assay format | Scientific Literature | |
18. | ALA4729246 | A | Inhibition of recombinant human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 mins by liquid scintillation counting method | Homo sapiens | 2 | ALA4725363 | assay format | Scientific Literature | |
19. | ALA4729247 | B | Selectivity index, ratio of IC50 for human PDE9A2 to IC50 for human PDE5A1 | Homo sapiens | 2 | ALA4725363 | assay format | Scientific Literature | |
20. | ALA4729248 | A | Inhibition of human PDE10A catalytic domain (449 to 770 residues) using [3H]-cAMP as substrate after 15 mins by liquid scintillation counting method | Homo sapiens | 2 | ALA4725363 | single protein format | Scientific Literature |