| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4670918 | A | Intrinsic clearance in mouse liver microsomes at 1 uM measured up to 60 mins by LC-MS analysis | Mus musculus | 3 | ALA4665812 | microsome format | Scientific Literature | |
| 2. | ALA4670919 | A | Ratio of apparent permeability across basolateral to apical over apical to basolateral side in human Caco2 cells at 5 uM after 2 hrs by transwell assay | Homo sapiens | 8 | ALA4665812 | cell-based format | Scientific Literature | |
| 3. | ALA4670920 | A | Apparent permeability across apical side to basolateral side in human Caco-2 cells at 5 uM after 2 hrs by transwell assay | Homo sapiens | 8 | ALA4665812 | cell-based format | Scientific Literature | |
| 4. | ALA4670923 | A | Stability of compound in mouse plasma assessed as parent compound remaining at 5 uM measured for 1 hr by LC-MS analysis | Mus musculus | 8 | ALA4665812 | cell-free format | Scientific Literature | |
| 5. | ALA4670924 | A | Stability of compound in human plasma assessed as parent compound remaining at 5 uM measured for 1 hr by LC-MS analysis | Homo sapiens | 8 | ALA4665812 | cell-free format | Scientific Literature | |
| 6. | ALA4670925 | P | Kinetic solubility of compound in HEPES buffer a pH 7.4 at 500 uM after 90 mins | 8 | ALA4665812 | small-molecule physicochemical format | Scientific Literature | ||
| 7. | ALA4670926 | P | Solubility of compound in aqueous buffer at pH 7.4 after 120 mins by turbidometric assay | 8 | ALA4665812 | small-molecule physicochemical format | Scientific Literature | ||
| 8. | ALA4670927 | B | Inhibiton of EGFR L858R/T790M mutant (unknown origin) expressed in human NCI-H1975 cells assessed as reduction in EGFR induced cell viability after 96 hrs by CellTiter-Glo assay | Homo sapiens | 8 | ALA4665812 | cell-based format | Scientific Literature | |
| 9. | ALA4670928 | B | Inhibiton of EGFR (unknown origin) expressed in human A431 cells assessed as reduction in EGFR induced cell viability after 96 hrs by CellTiter-Glo assay | Homo sapiens | 8 | ALA4665812 | cell-based format | Scientific Literature | |
| 10. | ALA4670929 | B | Inhibition of human N-terminal GST-tagged EGFR L858R/T790M mutant (669 to 1210 residues) expressed in baculovirus infected Sf9 insect cells using TK as substrate preincubated for 30 mins followed by substrate addition and measured after 20 mins by HTRF assay | Homo sapiens | 8 | ALA4665812 | cell-based format | Scientific Literature | |
| 11. | ALA4670930 | B | Inhibition of human N-terminal GST-tagged EGFR L858R mutant (669 to 1210 residues) expressed in baculovirus infected Sf9 insect cells using TK as substrate preincubated for 30 mins followed by substrate addition and measured after 15 mins by HTRF assay | Homo sapiens | 8 | ALA4665812 | cell-based format | Scientific Literature | |
| 12. | ALA4670931 | B | Inhibition of human N-terminal GST-tagged EGFR (669 to 1210 residues) expressed in baculovirus infected Sf9 insect cells using TK as substrate preincubated for 30 mins followed by substrate addition and measured after 25 mins by HTRF assay | Homo sapiens | 8 | ALA4665812 | cell-based format | Scientific Literature | |
| 13. | ALA4670932 | B | Potency index, ratio of neratinib Kinact to test compound Kinact for inhibition of C-terminal His6-tagged HER2-A775_G776insYVMA mutant (703 to 1029 residues) (unknown origin) expressed in Sf9 insect cells | Homo sapiens | 4 | ALA4665812 | cell-based format | Scientific Literature | |
| 14. | ALA4670933 | B | Potency index, ratio of afatinib Kinact to test compound Kinact for inhibition of C-terminal His6-tagged HER2-A775_G776insYVMA mutant (703 to 1029 residues) (unknown origin) expressed in Sf9 insect cells | Homo sapiens | 4 | ALA4665812 | cell-based format | Scientific Literature | |
| 15. | ALA4670934 | B | Inhibition of C-terminal His6-tagged HER2-A775_G776insYVMA mutant (703 to 1029 residues) (unknown origin) expressed in Sf9 insect cells assessed as ratio of Kinact to Ki using TK as substrate measured up to 2 to 40 mins by fluorescence assay | Homo sapiens | 6 | ALA4665812 | cell-based format | Scientific Literature | |
| 16. | ALA4670935 | B | Inhibition of C-terminal His6-tagged HER2-A775_G776insYVMA mutant (703 to 1029 residues) (unknown origin) expressed in Sf9 insect cells assessed as Kinact using TK as substrate measured up to 2 to 40 mins by fluorescence assay | Homo sapiens | 6 | ALA4665812 | cell-based format | Scientific Literature | |
| 17. | ALA4670936 | B | Inhibition of C-terminal His6-tagged HER2-A775_G776insYVMA mutant (703 to 1029 residues) (unknown origin) expressed in Sf9 insect cells using TK as substrate measured up to 2 to 40 mins by fluorescence assay | Homo sapiens | 6 | ALA4665812 | cell-based format | Scientific Literature | |
| 18. | ALA4670939 | B | Inhibition of S6 phosphorylation at T202/204 residues in human H1781 cells after 1 hrs by Western blot analysis | Homo sapiens | 2 | ALA4665812 | cell-based format | Scientific Literature | |
| 19. | ALA4670940 | B | Inhibition of MAPK phosphorylation at T202/204 residues in human H1781 cells after 1 hrs by Western blot analysis | Homo sapiens | 2 | ALA4665812 | cell-based format | Scientific Literature | |
| 20. | ALA4670941 | B | Inhibition of AKT phosphorylation at S473 residues in human H1781 cells after 1 hrs by Western blot analysis | Homo sapiens | 2 | ALA4665812 | cell-based format | Scientific Literature |
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