| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4667426 | F | Positive allosteric modulation of human M4 receptor/Gqi5 in presence of EC20 glutamate by calcium mobilization assay | Homo sapiens | 27 | assay format | Scientific Literature | ||
| 2. | ALA4667427 | F | Positive allosteric modulation of human M4 receptor/Gqi5 in presence of EC20 glutamate by calcium mobilization assay relative to acetylcholine | Homo sapiens | 26 | assay format | Scientific Literature | ||
| 3. | ALA4667428 | A | Positive allosteric modulation of human M2 receptor/Gqi5 in presence of EC20 glutamate by calcium mobilization assay | Homo sapiens | 22 | single protein format | Scientific Literature | ||
| 4. | ALA4667430 | B | Positive allosteric modulation of human M1 receptor | Homo sapiens | 22 | single protein format | Scientific Literature | ||
| 5. | ALA4667431 | B | Positive allosteric modulation of human M3 receptor | Homo sapiens | 22 | single protein format | Scientific Literature | ||
| 6. | ALA4667432 | B | Positive allosteric modulation of human M5 receptor | Homo sapiens | 22 | single protein format | Scientific Literature | ||
| 7. | ALA4667433 | A | Hepatic clearance in rat | Rattus norvegicus | 7 | assay format | Scientific Literature | ||
| 8. | ALA4667434 | A | Hepatic clearance in human | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 9. | ALA4667435 | A | Fraction unbound in rat plasma | Rattus norvegicus | 7 | cell-free format | Scientific Literature | ||
| 10. | ALA4667436 | A | Fraction unbound in human plasma | Homo sapiens | 7 | cell-free format | Scientific Literature | ||
| 11. | ALA4667437 | A | Fraction unbound in rat brain | Rattus norvegicus | 7 | tissue-based format | Scientific Literature | ||
| 12. | ALA4667438 | A | Brain to plasma permeability coefficient, Kp in Sprague-Dawley rat at 0.1 to 0.2 mg/kg, iv measured after 0.25 hrs | Rattus norvegicus | 7 | organism-based format | Scientific Literature | ||
| 13. | ALA4667439 | A | Unbound brain-to-plasma concentration ratio in Sprague-Dawley rat at 0.1 to 0.2 mg/kg, iv measured after 0.25 hrs | Rattus norvegicus | 7 | organism-based format | Scientific Literature | ||
| 14. | ALA4667440 | A | Substrate activity at human P-gp expressed in MDCK-MDR1 cells assessed as efflux ratio | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 15. | ALA4667441 | P | Distribution coefficient, log D of the compound pH 7.5 | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 16. | ALA4667442 | P | Solubility of the compound pH 7.5 | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 17. | ALA4667443 | P | Solubility of the compound in FaSSIF | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 18. | ALA4667444 | P | Solubility of the compound in simulated gastric fluid | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 19. | ALA4667445 | B | Positive allosteric modulation of rat M4 receptor | Rattus norvegicus | 1 | single protein format | Scientific Literature | ||
| 20. | ALA4667446 | B | Positive allosteric modulation of rat M4 receptor relative to acetylcholine | Rattus norvegicus | 1 | single protein format | Scientific Literature |
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