| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4731669 | B | Inhibition of CD73 in C57BL/6 mouse retina incubated for 1 hr by microscopic analysis | Mus musculus | 2 | tissue-based format | Scientific Literature | ||
| 2. | ALA4731670 | B | Inhibition of recombinant human C-terminal His-tagged CD73 (27 to 549 residues) expressed in Sf9 cells using [2,8-3H]-AMP as substrate incubated for 25 mins by scintillation counting method | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 3. | ALA4731671 | B | Inhibition of CD73 in human MDA-MB-231 cells using [2,8-3H]-AMP as substrate incubated for 25 mins by scintillation counting method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4731672 | B | Inhibition of recombinant rat CD73 expressed in Sf9 cells using [2,8-3H]-AMP as substrate incubated for 25 mins by scintillation counting method | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA4731673 | B | Selectivity index, ratio of Ki for rat C-terminal His-tagged CD73 expressed in Sf9 cells to Ki for recombinant human C-terminal His-tagged CD73 (27 to 549 residues) expressed in Sf9 cells | 1 | cell-based format | Scientific Literature | |||
| 6. | ALA4731674 | B | Inhibition of human NTPDase 1 expressed in human COS7 cells using ATP as substrate at 50 uM incubated for 5 mins followed by substrate addition and measured after 30 mins by capillary electrophoresis method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4731675 | B | Inhibition of human NTPDase 2 expressed in human COS7 cells using ATP as substrate at 50 uM incubated for 5 mins followed by substrate addition and measured after 30 mins by capillary electrophoresis method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4731676 | B | Inhibition of human NTPDase 3 expressed in human COS7 cells using ATP as substrate at 50 uM incubated for 5 mins followed by substrate addition and measured after 30 mins by capillary electrophoresis method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4731677 | B | Inhibition of human NTPDase 8 expressed in human COS7 cells using ATP as substrate at 50 uM incubated for 5 mins followed by substrate addition and measured after 30 mins by capillary electrophoresis method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4731678 | F | Effect on human P2Y12 expressed in CHO-PK1 cells assessed as beta arrestin recruitment at 10 uM by beta-arrestin assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4731679 | B | Inhibition of CD73 in human MDA-MB-231 cells incubated for 30 mins by anti-CD73 antibody and alexa flour 633 staining based confocal microscopy analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA4731680 | A | Effect on C57BL/6 mouse retina with CD73-/- deficient incubated for 1 hr by microscopic analysis | Mus musculus | 2 | tissue-based format | Scientific Literature | ||
| 13. | ALA4731681 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance measured for 60 mins | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 14. | ALA4731682 | A | Metabolic stability in human liver microsomes assessed as half life measured for 60 mins | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 15. | ALA4731683 | A | Cytotoxicity against human A549 cells assessed as reduction in cell growth at 1000 nM incubated for 48 hrs by CCK8 assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA4731684 | A | Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell growth at 10000 nM incubated for 24 hrs by FACS analysis | Homo sapiens | 2 | cell-based format | Scientific Literature |
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