| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4705238 | A | Agonist activity at EA-fragment beta-arrestin-tagged human MOR expressed in human U2OS cell membranes assessed as stimulation of [35S]-GTPgammaS binding after 60 mins by beta-galactosidase based scintillation counting method | Homo sapiens | 20 | ALA4699635 | cell membrane format | Scientific Literature | |
| 2. | ALA4705239 | F | Agonist activity at MOR/DOR in wild-type C57BL6 mouse spinal cord membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 60 mins by scintillation counting assay | Mus musculus | 3 | ALA4699635 | cell membrane format | Scientific Literature | |
| 3. | ALA4705240 | F | Antinociceptive activity in CD-1 mouse model of thermal-induced nociception at 1 nmol, icv measured up to 2 hrs in presence of DOR antagonist NTB by warm water tail-flick assay | Mus musculus | 1 | ALA4699635 | organism-based format | Scientific Literature | |
| 4. | ALA4705241 | A | Agonist activity at EA-fragment beta-arrestin-tagged human MOR expressed in human U2OS cell membranes assessed as stimulation beta-arrestin recruitment after 60 mins by Pathhunter chemiluminescence assay | Homo sapiens | 7 | ALA4699635 | cell membrane format | Scientific Literature | |
| 5. | ALA4705242 | F | Agonist activity at EA-fragment beta-arrestin-tagged human DOR expressed in human U2OS cell membranes assessed as stimulation of [35S]-GTPgammaS binding after 60 mins by beta-galactosidase based scintillation counting method | Homo sapiens | 15 | ALA4699635 | cell membrane format | Scientific Literature | |
| 6. | ALA4705243 | B | Agonist activity at EA-fragment beta-arrestin-tagged human DOR expressed in human U2OS cell membranes assessed as stimulation beta-arrestin recruitment after 60 mins by Pathhunter chemiluminescence assay | Homo sapiens | 11 | ALA4699635 | cell membrane format | Scientific Literature | |
| 7. | ALA4705244 | A | Agonist activity at EA-fragment beta-arrestin-tagged human MOR expressed in human U2OS cell membranes assessed as stimulation of [35S]-GTPgammaS binding at 10 uM after 60 mins by beta-galactosidase based scintillation counting method relative to DAMGO | Homo sapiens | 19 | ALA4699635 | cell membrane format | Scientific Literature | |
| 8. | ALA4705245 | A | Agonist activity at EA-fragment beta-arrestin-tagged human MOR expressed in human U2OS cell membranes assessed as stimulation beta-arrestin recruitment at 10 uM after 60 mins by Pathhunter Chemiluminescence assay relative to DAMGO | Homo sapiens | 19 | ALA4699635 | cell membrane format | Scientific Literature | |
| 9. | ALA4705246 | F | Agonist activity at EA-fragment beta-arrestin-tagged human DOR expressed in human U2OS cell membranes assessed as stimulation of [35S]-GTPgammaS binding at 10 uM after 60 mins by beta-galactosidase based scintillation counting method relative to DELT II | Homo sapiens | 19 | ALA4699635 | cell membrane format | Scientific Literature | |
| 10. | ALA4705247 | B | Agonist activity at EA-fragment beta-arrestin-tagged human MOR expressed in human U2OS cell membranes assessed as stimulation beta-arrestin recruitment at 10 uM after 60 mins by Pathhunter chemiluminescence assay relative to DELT II | Homo sapiens | 19 | ALA4699635 | cell membrane format | Scientific Literature | |
| 11. | ALA4705248 | F | Agonist activity at EA-fragment beta-arrestin-tagged human MOR/DOR expressed in human U2OS cell membranes assessed as stimulation of [35S]-GTPgammaS binding after 60 mins by beta-galactosidase based scintillation counting method | Homo sapiens | 19 | ALA4699635 | cell membrane format | Scientific Literature | |
| 12. | ALA4705249 | F | Agonist activity at EA-fragment beta-arrestin-tagged human MOR/DOR expressed in human U2OS cell membranes assessed as stimulation of [35S]-GTPgammaS binding at 10 uM after 60 mins by beta-galactosidase based scintillation counting method relative to DAMGO | Homo sapiens | 19 | ALA4699635 | cell membrane format | Scientific Literature | |
| 13. | ALA4705250 | B | Agonist activity at EA-fragment beta-arrestin-tagged human MOR/DOR expressed in human U2OS cell membranes assessed as stimulation beta-arrestin recruitment after 60 mins by Pathhunter chemiluminescence assay | Homo sapiens | 8 | ALA4699635 | cell membrane format | Scientific Literature | |
| 14. | ALA4705251 | B | Agonist activity at EA-fragment beta-arrestin-tagged human MOR/DOR expressed in human U2OS cell membranes assessed as stimulation beta-arrestin recruitment at 10 uM after 60 mins by Pathhunter chemiluminescence assay relative to DAMGO | Homo sapiens | 19 | ALA4699635 | cell membrane format | Scientific Literature | |
| 15. | ALA4705252 | A | Agonist activity at MOR in DOR knock out C57BL6 mouse spinal cord membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 60 mins by scintillation counting assay | Mus musculus | 3 | ALA4699635 | cell membrane format | Scientific Literature | |
| 16. | ALA4705253 | F | Agonist activity at DOR in MOR knock out C57BL6 mouse spinal cord membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 60 mins by scintillation counting assay | Mus musculus | 3 | ALA4699635 | cell membrane format | Scientific Literature | |
| 17. | ALA4705254 | F | Antinociceptive activity in CD-1 mouse model of thermal-induced nociception at 1 to 10 nmol, icv measured upto 2 hrs post-treatment by warm water tail-flick assay | Mus musculus | 1 | ALA4699635 | organism-based format | Scientific Literature | |
| 18. | ALA4705255 | F | Antinociceptive activity in CD-1 mouse model of thermal-induced nociception assessed as increase in antinociceptive area under curve at 1 to 10 nmol, icv measured upto 2 hrs post-treatment by warm water tail-flick assay | Mus musculus | 1 | ALA4699635 | organism-based format | Scientific Literature | |
| 19. | ALA4705256 | F | Antinociceptive activity in CD-1 mouse model of thermal-induced nociception at 1 nmol, icv measured up to 2 hrs in presence of DOR/MOR heteromer antagonist D24M by warm water tail-flick assay | Mus musculus | 1 | ALA4699635 | organism-based format | Scientific Literature | |
| 20. | ALA4705257 | F | Antinociceptive activity in CD-1 mouse model of thermal-induced nociception at 1 nmol, icv measured up to 2 hrs in presence of DOR antagonist NTI by warm water tail-flick assay | Mus musculus | 1 | ALA4699635 | organism-based format | Scientific Literature |
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