# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4768557 | ADME | Cytotoxicity against human Platelet assessed as increase in LDH leakage at 200 uM after 10 mins by LDH assay | Homo sapiens | 14 | ALA4765278 | cell-based format | Scientific Literature | |
2. | ALA4768558 | Functional | Inhibition of collagen-induced platelet aggregation in human platelet preincubated for 5 mins followed by collagen-stimulation and measured after 6 mins by lumi-aggregometric method | Homo sapiens | 12 | ALA4765278 | tissue-based format | Scientific Literature | |
3. | ALA4768559 | Functional | Inhibition of TRAP6-induced platelet aggregation in human platelet preincubated for 5 mins followed by TRAP6-stimulation and measured after 6 mins by lumi-aggregometric method | Homo sapiens | 12 | ALA4765278 | tissue-based format | Scientific Literature | |
4. | ALA4768560 | Functional | Selectivity index, ratio of IC50 for inhibition of TRAP6-induced platelet aggregation in human platelet to IC50 for inhibition of collagen-induced platelet aggregation in human platelet | Homo sapiens | 12 | ALA4765278 | tissue-based format | Scientific Literature | |
5. | ALA4768561 | Functional | Inhibition of collagen-induced platelet aggregation in human platelet preincubated for 5 mins followed by 2 ug/ml collagen-stimulation and measured after 6 mins by lumi-aggregometric method relative to control | Homo sapiens | 2 | ALA4765278 | tissue-based format | Scientific Literature | |
6. | ALA4768562 | Functional | Inhibition of TRAP6-induced platelet aggregation in human platelet preincubated for 5 mins followed by 10 uM TRAP6-stimulation and measured after 6 mins by lumi-aggregometric method relative to control | Homo sapiens | 2 | ALA4765278 | tissue-based format | Scientific Literature | |
7. | ALA4768563 | Functional | Effect on platelet activation in human collagen/TRAP6-inducrd human Platelet assessed as positive subpopulation cells at 2 to 20 uM by annexin V-FITC staining based flow cytometric analysis | Homo sapiens | 2 | ALA4765278 | tissue-based format | Scientific Literature | |
8. | ALA4768564 | Functional | Antiplatelet activity in human Platelet assessed as inhibition of collagen-induced p-selectin protein expression at 2 to 20 uM by flow cytometric analysis | Homo sapiens | 1 | ALA4765278 | cell-based format | Scientific Literature | |
9. | ALA4768566 | Functional | Antiplatelet activity in human Platelet assessed as inhibition of collagen-induced GP2a/3b activation at 2 to 20 uM by flow cytometric analysis | Homo sapiens | 1 | ALA4765278 | cell-based format | Scientific Literature | |
10. | ALA4768568 | Functional | Antiplatelet activity in human Platelet assessed as intracellular calcium level at 2 to 20 uM preincubated for 5 mins and measured for 15 sec by Fluo-3-AM staining based assay | Homo sapiens | 2 | ALA4765278 | cell-based format | Scientific Literature | |
11. | ALA4768570 | Functional | Antiplatelet activity in human Platelet assessed as inhibition of collagen-induced ATP secretion at 2 to 20 uM by Cell Titer-Glo luminescent cell viability assay | Homo sapiens | 1 | ALA4765278 | cell-based format | Scientific Literature | |
12. | ALA4768572 | Functional | Antiplatelet activity in human Platelet assessed as intracellular NADH level at 2 to 20 uM by fluorescence assay | Homo sapiens | 2 | ALA4765278 | cell-based format | Scientific Literature | |
13. | ALA4768573 | Functional | Antiplatelet activity in human Platelet assessed as mitochondrial membrane potential loss at 2 to 20 uM by TMRM staining based flow cytometric analysis | Homo sapiens | 1 | ALA4765278 | cell-based format | Scientific Literature | |
14. | ALA4768574 | Functional | Antiplatelet activity in human Platelet assessed as ROS production at 2 to 20 uM by DHE staining based flow cytometric analysis | Homo sapiens | 1 | ALA4765278 | cell-based format | Scientific Literature | |
15. | ALA4768575 | Functional | Antiplatelet activity in human Platelet assessed as intracellular ATP level at 2 to 20 uM by by Cell Titer-Glo luminescent cell viability assay | Homo sapiens | 1 | ALA4765278 | cell-based format | Scientific Literature |