# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4713356 | Functional | Antiproliferative activity against human PC-9 cells harboring EGFR L858R mutant by MTT assay | Homo sapiens | 14 | ALA4706659 | cell-based format | Scientific Literature | |
2. | ALA4713357 | Functional | Antiproliferative activity against human NCI-H1975 cells harboring EGFR T790M/L858R mutant by MTT assay | Homo sapiens | 14 | ALA4706659 | cell-based format | Scientific Literature | |
3. | ALA4713358 | Functional | Antiproliferative activity against human NCI-H292 cells harboring wild-type EGFR by MTT assay | Homo sapiens | 14 | ALA4706659 | cell-based format | Scientific Literature | |
4. | ALA4713359 | Functional | Selectivity ratio of IC50 for antiproliferative activity against human NCI-H292 cells harboring wild-type EGFR to IC50 for antiproliferative activity against human NCI-H1975 cells harboring EGFR T790M/L858R mutant | Homo sapiens | 14 | ALA4706659 | cell-based format | Scientific Literature | |
5. | ALA4713360 | Binding | Inhibition of recombinant human GST-tagged EGFR T790M/L858R double mutant (668 to 1210 residues) expressed in baculovirus expression system using Tyr 4 as substrate incubated for 60 mins by Z'-Lyte assay | Homo sapiens | 2 | ALA4706659 | assay format | Scientific Literature | |
6. | ALA4713361 | Binding | Inhibition of human recombinant GST-tagged EGFR L858R mutant expressed in baculovirus expression system using tyrosine 4 peptide as substrate after 60 mins in presence of ATP FRET based Z'-LYTE assay | Homo sapiens | 2 | ALA4706659 | assay format | Scientific Literature | |
7. | ALA4713362 | ADME | Inhibition of recombinant human GST-tagged EGFR expressed in baculovirus expression system using tyr-04 peptide as substrate incubated for 60 mins in presence of ATP by Z'-LYTE assay | Homo sapiens | 2 | ALA4706659 | assay format | Scientific Literature | |
8. | ALA4713363 | Binding | Selectivity ratio of IC50 for inhibition of recombinant human GST-tagged EGFR expressed in baculovirus expression system to IC50 for inhibition of recombinant human GST-tagged EGFR T790M/L858R double mutant (668 to 1210 residues) expressed in baculovirus expression system | Homo sapiens | 2 | ALA4706659 | assay format | Scientific Literature | |
9. | ALA4713364 | Unassigned | Selectivity ratio of IC50 for HK-2 cells to IC50 for antiproliferative activity against human NCI-H1975 cells | Homo sapiens | 2 | ALA4706659 | cell-based format | Scientific Literature | |
10. | ALA4713365 | ADME | Cytotoxicity against human L02 cells assessed as reduction in cell viability by MTT assay | Homo sapiens | 2 | ALA4706659 | cell-based format | Scientific Literature | |
11. | ALA4713366 | ADME | Cytotoxicity against HK-2 cells assessed as reduction in cell viability by MTT assay | Homo sapiens | 2 | ALA4706659 | cell-based format | Scientific Literature | |
12. | ALA4713367 | ADME | Cytotoxicity against HLF cells assessed as reduction in cell viability by MTT assay | Homo sapiens | 2 | ALA4706659 | cell-based format | Scientific Literature | |
13. | ALA4713368 | ADME | Cytotoxicity against HEK293-A cells assessed as reduction in cell viability by MTT assay | Homo sapiens | 2 | ALA4706659 | cell-based format | Scientific Literature | |
14. | ALA4713369 | Toxicity | Selectivity ratio of IC50 for human L02 cells to IC50 for antiproliferative activity against human NCI-H1975 cells | Homo sapiens | 2 | ALA4706659 | cell-based format | Scientific Literature | |
15. | ALA4713370 | Unassigned | Selectivity ratio of IC50 for HLF cells to IC50 for antiproliferative activity against human NCI-H1975 cells | Homo sapiens | 2 | ALA4706659 | cell-based format | Scientific Literature | |
16. | ALA4713371 | Toxicity | Selectivity ratio of IC50 for HEK293-A cells to IC50 for antiproliferative activity against human NCI-H1975 cells | Homo sapiens | 2 | ALA4706659 | cell-based format | Scientific Literature | |
17. | ALA4713372 | Functional | Antimigratory activity against human NCI-H1975 cells harboring EGFR T790M/L858R mutant assessed as inhibition of cell migration at 3 nM measured after 24 hrs by phase contrast microscopic analysis relative to control | Homo sapiens | 1 | ALA4706659 | cell-based format | Scientific Literature | |
18. | ALA4713373 | Functional | Antimigratory activity against human NCI-H1975 cells harboring EGFR T790M/L858R mutant assessed as inhibition of cell migration at 3 nM measured after 48 hrs by phase contrast microscopic analysis relative to control | Homo sapiens | 1 | ALA4706659 | cell-based format | Scientific Literature | |
19. | ALA4713374 | Functional | Antimigratory activity against human NCI-H1975 cells harboring EGFR T790M/L858R mutant assessed as inhibition of cell migration at 9 nM measured after 24 hrs by phase contrast microscopic analysis relative to control | Homo sapiens | 1 | ALA4706659 | cell-based format | Scientific Literature | |
20. | ALA4713375 | Functional | Antimigratory activity against human NCI-H1975 cells harboring EGFR T790M/L858R mutant assessed as inhibition of cell migration at 9 nM measured after 48 hrs by phase contrast microscopic analysis relative to control | Homo sapiens | 1 | ALA4706659 | cell-based format | Scientific Literature |