# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4705577 | B | Antagonist activity at rat alpha3beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential incubated for 5 mins by voltage-clamp assay | Rattus norvegicus | 17 | cell-based format | Scientific Literature | ||
2. | ALA4705578 | B | Antagonist activity at rat alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential incubated for 5 mins by voltage-clamp assay | Rattus norvegicus | 17 | cell-based format | Scientific Literature | ||
3. | ALA4705579 | B | Selectivity index, ratio of IC50 for rat alpha3beta4 nAChR expressed in Xenopus laevis oocytes to IC50 for rat alpha3beta2 nAChR expressed in Xenopus laevis oocytes | Rattus norvegicus | 17 | cell-based format | Scientific Literature | ||
4. | ALA4705580 | B | Displacement of [125I]-alpha-bungarotoxin from Aplysia californica C-terminal His6-tagged N-terminal gp67 signal peptide-tagged acetylcholine receptor binding protein expressed in Hi5 insect cells preincubated for 3 hrs followed by [125I]-alpha-bungarotoxin measured after 5 mins by radioligand binding assay | Aplysia californica | 12 | cell-based format | Scientific Literature | ||
5. | ALA4705581 | B | Antagonist activity at rat alpha3beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential incubated for 5 mins by voltage-clamp assay relative to LvIA IC50 | Rattus norvegicus | 16 | cell-based format | Scientific Literature | ||
6. | ALA4705595 | B | Antagonist activity at rat alpha3beta2 nAChR S168I mutant expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential measured after 5 mins by voltage-clamp assay | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
7. | ALA4705597 | B | Antagonist activity at rat alpha3beta2 nAChR S168I mutant expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response by measuring recovery of ACh-induced response time at 10 nM with -70 mV holding potential measured after 5 mins voltage-clamp assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
8. | ALA4705598 | B | Antagonist activity at rat alpha3beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response by measuring recovery of ACh-induced response time at 10 nM with -70 mV holding potential measured after 5 mins voltage-clamp assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
9. | ALA4705599 | B | Displacement of [125I]-alpha-bungarotoxin from Aplysia californica C-terminal His6-tagged N-terminal gp67 signal peptide-tagged acetylcholine receptor binding protein expressed in Hi5 insect cells preincubated for 3 hrs followed by [125I]-alpha-bungarotoxin measured after 5 mins by radioligand binding assay relative to LvIA IC50 | Aplysia californica | 11 | cell-based format | Scientific Literature | ||
10. | ALA4705600 | B | Antagonist activity at rat alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential incubated for 5 mins by voltage-clamp assay relative to LvIA IC50 | Rattus norvegicus | 16 | cell-based format | Scientific Literature | ||
11. | ALA4705612 | B | Selectivity ratio of IC50 for antagonist activity at rat alpha3beta2 nAChR expressed in Xenopus laevis oocytes to IC50 for antagonist activity at rat alpha3beta2 nAChR S168I mutant expressed in Xenopus laevis oocytes | Rattus norvegicus | 2 | cell-based format | Scientific Literature |