| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4672631 | B | Selectivity index, ratio of IC50 for inhibition of 6xHis-tagged rat recombinant PDE10A2 expressed in Sf9 cells to IC50 for Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells | 7 | ALA4665888 | cell-based format | Scientific Literature | ||
| 2. | ALA4672632 | B | Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation counting method | Homo sapiens | 44 | ALA4665888 | cell-based format | Scientific Literature | |
| 3. | ALA4672633 | B | Inhibition of 6xHis-tagged human recombinant PDE3A expressed in Sf9 cells in presence of [3H]-cAMP and cAMP incubated for 60 mins by scintillation counting method | Homo sapiens | 36 | ALA4665888 | cell-based format | Scientific Literature | |
| 4. | ALA4672634 | B | Inhibition of 6xHis-tagged rat recombinant PDE10A2 expressed in Sf9 cells in presence of [3H]-cAMP and cAMP incubated for 60 mins by scintillation counting method | Rattus norvegicus | 38 | ALA4665888 | cell-based format | Scientific Literature | |
| 5. | ALA4672640 | B | Selectivity index, ratio of IC50 for inhibition of 6xHis-tagged human recombinant PDE3A expressed in Sf9 cells to IC50 for Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells | Homo sapiens | 11 | ALA4665888 | cell-based format | Scientific Literature | |
| 6. | ALA4672643 | P | Solubility in pH 7.4 buffer | 8 | ALA4665888 | small-molecule physicochemical format | Scientific Literature | ||
| 7. | ALA4672644 | A | Inhibition of CYP3A4 in human liver microsomes by LC-MS analysis at 10 uM relative to control | Homo sapiens | 7 | ALA4665888 | microsome format | Scientific Literature | |
| 8. | ALA4672645 | A | Inhibition of CYP2C8 in human liver microsomes by LC-MS analysis at 10 uM relative to control | Homo sapiens | 4 | ALA4665888 | microsome format | Scientific Literature | |
| 9. | ALA4672646 | A | Inhibition of CYP2C9 in human liver microsomes by LC-MS analysis at 10 uM relative to control | Homo sapiens | 7 | ALA4665888 | microsome format | Scientific Literature | |
| 10. | ALA4672647 | A | Inhibition of CYP2C19 in human liver microsomes by LC-MS analysis at 10 uM relative to control | Homo sapiens | 7 | ALA4665888 | microsome format | Scientific Literature | |
| 11. | ALA4672648 | A | Inhibition of CYP2D6 in human liver microsomes by LC-MS analysis at 10 uM relative to control | Homo sapiens | 7 | ALA4665888 | microsome format | Scientific Literature | |
| 12. | ALA4672649 | A | Inhibition of CYP1A2 in human liver microsomes by LC-MS analysis at 10 uM relative to control | Homo sapiens | 7 | ALA4665888 | microsome format | Scientific Literature | |
| 13. | ALA4672656 | A | Intrinsic clearance in rat liver microsomes at 1 uM incubated for 60 mins | Rattus norvegicus | 8 | ALA4665888 | microsome format | Scientific Literature | |
| 14. | ALA4672657 | A | Intrinsic clearance in human liver microsomes at 1 uM incubated for 60 mins | Homo sapiens | 8 | ALA4665888 | microsome format | Scientific Literature | |
| 15. | ALA4672658 | A | Half life in rat liver microsomes at 1 uM | Rattus norvegicus | 8 | ALA4665888 | microsome format | Scientific Literature | |
| 16. | ALA4672659 | A | Half life in human liver microsomes at 1 uM | Homo sapiens | 8 | ALA4665888 | microsome format | Scientific Literature |
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