# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4682603 | B | Inhibition of human DNMT3B expressed in Escherichia coli Rosetta-gamiTM 2(DE3) pLysS competent cells using biotinylated 6-FAM double strand DNA comprising unique CpG site [3H]-SAM incubated for 1 hrs by fluorescence based assay | Homo sapiens | 14 | ALA4680123 | cell-based format | Scientific Literature | |
2. | ALA4682604 | F | Cytotoxicity against human KG-1 cells assessed as reduction in cell viability measured after 72 hrs by APTlite one step luminescence assay | Homo sapiens | 4 | ALA4680123 | cell-based format | Scientific Literature | |
3. | ALA4682605 | F | Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs by APTlite one step luminescence assay | Homo sapiens | 4 | ALA4680123 | cell-based format | Scientific Literature | |
4. | ALA4682608 | P | Chemical stability of compound in DNMT3A-c enzyme buffer assessed as half life at 1 mM by HPLC analysis | 7 | ALA4680123 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA4682609 | B | Inhibition of human DNMT3B in human KG-1 cells expressing cmv-firefly luciferase assessed as increase in luminescence incubated for 24 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 4 | ALA4680123 | cell-based format | Scientific Literature | |
6. | ALA4682610 | B | Inhibition of human DNMT3B in human KG-1 cells expressing cmv-firefly luciferase assessed as increase in luminescence at 5 uM incubated for 24 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 3 | ALA4680123 | cell-based format | Scientific Literature |