Antitumour activity against Walker 256 adenocarcinoma cells implanted in Wistar rat assessed as increase in animal survival rate by measuring T/C ratio at 2.5 mg/kg, ip qd for 3 days administered on day 3,4,5 after tumor cell transplantation
Antitumour activity against human PANC-1 cells xenografted in Crl:Nu-Foxnl nu mouse assessed as inhibition of tumour growth at total effective dose of 16 mg/kg, iv measured on day 33
Antitumour activity against human MIA PaCa-2 cells xenografted in Crl:Nu-Foxnl nu mouse assessed as inhibition of tumour growth at total effective dose of 12 mg/kg, ip measured on day 15
Antitumour activity against human BXPC-3 cells xenografted in Crl:Nu-Foxnl nu mouse assessed as inhibition of tumour growth at total effective dose of 16 mg/kg, iv measured on day 44
Antitumour activity against human BXPC-3 cells xenografted in Crl:Nu-Foxnl nu mouse assessed as inhibition of tumour growth at total effective dose of 16 mg/kg, iv measured on day 32
Antitumour activity against human ASPC1 cells xenografted in Crl:Nu-Foxnl nu mouse assessed as inhibition of tumour growth at total effective dose of 16 mg/kg, iv measured on day 39
Antitumour activity against human DU-145 cells xenografted in Crl:Nu-Foxnl nu mouse assessed as inhibition of tumour growth at total effective dose of 16 mg/kg, iv measured on day 33
Antitumour activity against human MDA-MB-231 cells xenografted in Crl:Nu-Foxnl nu mouse assessed as inhibition of tumour growth at total effective dose of 32 mg/kg, iv measured on day 32