# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4689587 | B | Inhibition of HDAC4 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assay | Homo sapiens | 20 | ALA4680373 | single protein format | Scientific Literature | |
2. | ALA4689588 | B | Inhibition of HDAC5 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assay | Homo sapiens | 3 | ALA4680373 | single protein format | Scientific Literature | |
3. | ALA4689589 | B | Inhibition of HDAC7 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assay | Homo sapiens | 3 | ALA4680373 | single protein format | Scientific Literature | |
4. | ALA4689590 | B | Inhibition of HDAC9 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assay | Homo sapiens | 3 | ALA4680373 | single protein format | Scientific Literature | |
5. | ALA4689591 | A | Inhibition of HDAC1 (unknown origin) using Ac-Arg-Gly-Lys(Ac) as substrate by fluorogenic assay | Homo sapiens | 3 | ALA4680373 | single protein format | Scientific Literature | |
6. | ALA4689592 | A | Inhibition of HDAC2 (unknown origin) using Ac-Arg-Gly-Lys(Ac) as substrate by fluorogenic assay | Homo sapiens | 3 | ALA4680373 | single protein format | Scientific Literature | |
7. | ALA4689593 | A | Inhibition of HDAC3/NCOR2 (unknown origin) using Boc-Lys(Ac) as substrate by fluorogenic assay | Homo sapiens | 3 | ALA4680373 | protein complex format | Scientific Literature | |
8. | ALA4689594 | A | Inhibition of HDAC8 (unknown origin) using Boc-Lys(TFA) as substrate by fluorogenic assay | Homo sapiens | 3 | ALA4680373 | single protein format | Scientific Literature | |
9. | ALA4689595 | A | Inhibition of HDAC6 (unknown origin) expressed in human HEK-Freestyle cells using Boc-Lys(Ac) as substrate by fluorogenic assay | Homo sapiens | 3 | ALA4680373 | cell-based format | Scientific Literature | |
10. | ALA4689596 | A | Inhibition of Class 1/2b HDAC in human Jurkat E6.1 cells using Boc-Lys-(Ac)-AMC as substrate by fluorogenic assay | Homo sapiens | 16 | ALA4680373 | cell-based format | Scientific Literature | |
11. | ALA4689597 | B | Inhibition of Class 2A HDAC4 in human Jurkat E6.1 cells using Boc-Lys-(TFA)-AMC as substrate by fluorogenic assay | Homo sapiens | 20 | ALA4680373 | cell-based format | Scientific Literature | |
12. | ALA4689598 | A | Intrinsic Clearance in mouse liver microsomes | Mus musculus | 10 | ALA4680373 | microsome format | Scientific Literature | |
13. | ALA4689599 | A | Efflux ratio of permeability from basolateral to apical over apical to basolateral side in dog MDCK-MDR1 cells relative to wild type MDCK cells | Canis lupus familiaris | 10 | ALA4680373 | cell-based format | Scientific Literature | |
14. | ALA4689601 | P | Kinetic solubility of the compound | 10 | ALA4680373 | small-molecule physicochemical format | Scientific Literature | ||
15. | ALA4689603 | A | Oral bioavailability in C57BL/6J mouse at 11.5 mg/kg administered via gavage by LC-MS/MS analysis | Mus musculus | 1 | ALA4680373 | organism-based format | Scientific Literature | |
16. | ALA4689604 | B | Inhibition of Class 2A HDAC in human HEK293 cells using Boc-Lys(TFA) as substrate by fluorogenic assay | Homo sapiens | 1 | ALA4680373 | cell-based format | Scientific Literature | |
17. | ALA4689606 | U | Selectivity index, ratio of IC50 for Class 1/2b HDAC in human Jurkat E6.1 cells using Boc-Lys-(Ac)-AMC as substrate to IC50 for Class 2A HDAC4 in human Jurkat E6.1 cells using Boc-Lys-(TFA)-AMC as substrate by fluorogenic assay | Homo sapiens | 16 | ALA4680373 | cell-based format | Scientific Literature | |
18. | ALA4689608 | A | Inhibition of Class 1 HDAC in human HEK293 cells using H4K12 as substrate by fluorogenic assay | Homo sapiens | 1 | ALA4680373 | cell-based format | Scientific Literature | |
19. | ALA4689609 | A | Inhibition of Class 2b HDAC in human HEK293 cells using alpha-tubulin as substrate by fluorogenic assay | Homo sapiens | 1 | ALA4680373 | cell-based format | Scientific Literature | |
20. | ALA4689610 | U | Selectivity index, ratio of IC50 for Class 1 HDAC in human HEK293 cells using H4K12 as substrate to IC50 for Class 2A HDAC in human HEK293 cells using Boc-Lys(TFA) as substrate | Homo sapiens | 1 | ALA4680373 | cell-based format | Scientific Literature |