# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4729140 | B | Inhibition of recombinant full-length Plasmodium falciparum 3D7 CLK3 using ULight-labelled CFFKNIVTPRTPPPSQGK as substrate measured after 1 hr by TR-FRET assay | Plasmodium falciparum 3D7 | 15 | assay format | Scientific Literature | ||
2. | ALA4729141 | F | Antimalarial activity against chloroquine-sensitive synchronized ring stage of Plasmodium falciparum 3D7 incubated for 48 to 52 hrs by SYBR green 1 dye based assay | Plasmodium falciparum | 16 | organism-based format | Scientific Literature | ||
3. | ALA4729142 | P | Distribution coefficient, log D of the compound at pH 7.4 by HPLC method | 15 | small-molecule physicochemical format | Scientific Literature | |||
4. | ALA4729143 | A | Intrinsic clearance in CD1 mouse liver microsomes assessed per gram of tissue at 1 uM measured up to 30 mins in presence of NADPH by HPLC analysis | Mus musculus | 15 | microsome format | Scientific Literature | ||
5. | ALA4729144 | F | Antimalarial activity against chloroquine-sensitive synchronized ring stage of Plasmodium falciparum 3D7 harboring CLK3 G449P mutant incubated for 48 to 52 hrs by SYBR green 1 dye based assay | Plasmodium falciparum | 2 | organism-based format | Scientific Literature | ||
6. | ALA4729145 | F | Selectivity ratio of EC50 for antimalarial activity against chloroquine-sensitive synchronized ring stage of Plasmodium falciparum 3D7 harboring CLK3 G449P mutant to EC50 for antimalarial activity against chloroquine-sensitive synchronized ring stage of Plasmodium falciparum 3D7 | Plasmodium falciparum | 2 | assay format | Scientific Literature | ||
7. | ALA4729146 | F | Antimalarial activity against Plasmodium falciparum isolate GB0006 assessed as reduction in parasitemia at 1 to 10 times EC50 supplemented with fresh medium containing compounds every 24 hrs for 72 hrs relative to control | Plasmodium falciparum | 2 | organism-based format | Scientific Literature | ||
8. | ALA4729147 | F | Antimalarial activity against Plasmodium falciparum isolate GB0004 assessed as reduction in parasitemia at 1 to 10 times EC50 supplemented with fresh medium containing compounds every 24 hrs for 72 hrs relative to control | Plasmodium falciparum | 2 | organism-based format | Scientific Literature | ||
9. | ALA4729148 | F | Antimalarial activity against Plasmodium falciparum isolate GB0021 assessed as reduction in parasitemia at 1 to 10 times EC50 supplemented with fresh medium containing compounds every 24 hrs for 72 hrs relative to control | Plasmodium falciparum | 2 | organism-based format | Scientific Literature | ||
10. | ALA4729149 | F | Antimalarial activity against Plasmodium falciparum isolate GB0048 assessed as reduction in parasitemia at 1 to 10 times EC50 supplemented with fresh medium containing compounds every 24 hrs for 72 hrs relative to control | Plasmodium falciparum | 2 | organism-based format | Scientific Literature | ||
11. | ALA4729150 | F | Antimalarial activity against Plasmodium falciparum isolate GB0071 assessed as reduction in parasitemia at 1 to 10 times EC50 supplemented with fresh medium containing compounds every 24 hrs for 72 hrs relative to control | Plasmodium falciparum | 2 | organism-based format | Scientific Literature | ||
12. | ALA4729151 | F | Antimalarial activity against Plasmodium falciparum isolate GB0087 assessed as reduction in parasitemia at 1 to 10 times EC50 supplemented with fresh medium containing compounds every 24 hrs for 72 hrs relative to control | Plasmodium falciparum | 2 | organism-based format | Scientific Literature | ||
13. | ALA4729158 | F | Antimalarial activity against Plasmodium falciparum isolate GB0020 assessed as reduction in parasitemia at 1 to 10 times EC50 supplemented with fresh medium containing compounds every 24 hrs for 72 hrs relative to control | Plasmodium falciparum | 1 | organism-based format | Scientific Literature | ||
14. | ALA4729159 | F | Antimalarial activity against Plasmodium falciparum isolate GB002 assessed as reduction in parasitemia at 1 to 10 times EC50 supplemented with fresh medium containing compounds every 24 hrs for 72 hrs relative to control | Plasmodium falciparum | 1 | organism-based format | Scientific Literature | ||
15. | ALA4729160 | F | Antimalarial activity against Plasmodium falciparum isolate GB0026 assessed as reduction in parasitemia at 1 to 10 times EC50 supplemented with fresh medium containing compounds every 24 hrs for 72 hrs relative to control | Plasmodium falciparum | 1 | organism-based format | Scientific Literature | ||
16. | ALA5251363 | B | Inhibition of recombinant human CDK5/p25 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis | Homo sapiens | 56 | cell-based format | Scientific Literature | ||
17. | ALA5251364 | B | Inhibition of recombinant human CK1epsilon expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis | Homo sapiens | 56 | cell-based format | Scientific Literature | ||
18. | ALA5251365 | B | Inhibition of recombinant human CLK1 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis | Homo sapiens | 56 | cell-based format | Scientific Literature | ||
19. | ALA5251366 | B | Inhibition of recombinant human CLK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis | Homo sapiens | 56 | cell-based format | Scientific Literature | ||
20. | ALA5251367 | B | Inhibition of recombinant human CLK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis | Homo sapiens | 56 | cell-based format | Scientific Literature |