# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4766119 | Functional | Antiangiogenesis activity in EGFP-labelled zebrafish embryo assessed as reduction in formation of dorsal aorta at 1.25 to 5 uM incubated for overnight by fluorescence microscopic analysis | Danio rerio | 1 | ALA4765233 | organism-based format | Scientific Literature | |
2. | ALA4766120 | Functional | Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 55 | ALA4765233 | cell-based format | Scientific Literature | |
3. | ALA4766121 | Functional | Antiproliferative activity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 55 | ALA4765233 | cell-based format | Scientific Literature | |
4. | ALA4766122 | ADME | Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 55 | ALA4765233 | cell-based format | Scientific Literature | |
5. | ALA4766123 | Functional | Antitumor activity against human MDA-MB-231 cells xenografted in SCID mouse assessed as tumor growth inhibition at 40 mg/kg, po qd for 15 days and measured every 3 days | Homo sapiens | 7 | ALA4765233 | organism-based format | Scientific Literature | |
6. | ALA4766124 | Functional | Antitumor activity against human MDA-MB-231 cells xenografted in SCID mouse assessed as tumor growth inhibition at 40 mg/kg, po qd for 21 days and measured every 3 days | Homo sapiens | 7 | ALA4765233 | organism-based format | Scientific Literature | |
7. | ALA4766125 | Toxicity | Toxicity in SCID mouse xenografted with MDA-MB-231 cells assessed as change in body weight at 40 mg/kg, po qd for 15 days and measured every 3 days | Mus musculus | 7 | ALA4765233 | organism-based format | Scientific Literature | |
8. | ALA4766127 | Toxicity | Toxicity in SCID mouse xenografted with MDA-MB-231 cells assessed as animal death at 40 mg/kg, po qd for 15 days | Mus musculus | 7 | ALA4765233 | organism-based format | Scientific Literature | |
9. | ALA4766129 | Binding | Inhibition of human full length recombinant Src using Cdc2 peptide as substrate incubated for 40 mins in presence of [gamma33P-ATP] by radiometric scintillation counting analysis | Homo sapiens | 1 | ALA4765233 | single protein format | Scientific Literature | |
10. | ALA4766130 | Binding | Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by automated Qpatch electrophysiological assay | Homo sapiens | 16 | ALA4765233 | cell-based format | Scientific Literature | |
11. | ALA4766133 | ADME | Half-life in Sprague-Dawley rat at 10 mg/kg, po administered via gavage by LC-MS analysis | Rattus norvegicus | 2 | ALA4765233 | organism-based format | Scientific Literature | |
12. | ALA4766134 | ADME | AUC (0 to t) in Sprague-Dawley rat at 10 mg/kg, po administered via gavage by LC-MS analysis | Rattus norvegicus | 2 | ALA4765233 | organism-based format | Scientific Literature | |
13. | ALA4766135 | ADME | AUC (0 to infinity) in Sprague-Dawley rat at 10 mg/kg, po administered via gavage by LC-MS analysis | Rattus norvegicus | 2 | ALA4765233 | organism-based format | Scientific Literature | |
14. | ALA4766136 | ADME | Tmax in Sprague-Dawley rat at 10 mg/kg, po administered via gavage by LC-MS analysis | Rattus norvegicus | 2 | ALA4765233 | organism-based format | Scientific Literature | |
15. | ALA4766137 | ADME | Cmax in Sprague-Dawley rat at 10 mg/kg, po administered via gavage by LC-MS analysis | Rattus norvegicus | 2 | ALA4765233 | organism-based format | Scientific Literature | |
16. | ALA4766138 | ADME | Metabolic stability in mouse liver microsomes assessed as parent compound remaining at 1 uM measured after 60 mins in presence of NADPH by HPLC-MS/MS analysis | Mus musculus | 1 | ALA4765233 | microsome format | Scientific Literature | |
17. | ALA4766139 | ADME | Metabolic stability in rat liver microsomes assessed as parent compound remaining at 1 uM measured after 60 mins in presence of NADPH by HPLC-MS/MS analysis | Rattus norvegicus | 1 | ALA4765233 | microsome format | Scientific Literature | |
18. | ALA4766140 | ADME | Metabolic stability in dog liver microsomes assessed as parent compound remaining at 1 uM measured after 60 mins in presence of NADPH by HPLC-MS/MS analysis | Canis lupus familiaris | 1 | ALA4765233 | microsome format | Scientific Literature | |
19. | ALA4766141 | ADME | Metabolic stability in monkey liver microsomes assessed as parent compound remaining at 1 uM measured after 60 mins in presence of NADPH by HPLC-MS/MS analysis | Macaca mulatta | 1 | ALA4765233 | microsome format | Scientific Literature | |
20. | ALA4766142 | ADME | Metabolic stability in human liver microsomes assessed as parent compound remaining at 1 uM measured after 60 mins in presence of NADPH by HPLC-MS/MS analysis | Homo sapiens | 1 | ALA4765233 | microsome format | Scientific Literature |