| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4774027 | B | Inhibition of HDAC in human HeLa cell extracts assessed as inhibition of substrate deacetylation using Boc-Lys (q-Ac)-AMC as substrate incubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence based assay | Homo sapiens | 30 | tissue-based format | Scientific Literature | ||
| 2. | ALA4774028 | B | Inhibition of HDAC in human MDA-MB-231 cells assessed as increase in acetylated Histone H3 incubated for 8 hrs by Western blot analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 3. | ALA4774029 | B | Inhibition of HDAC in human MDA-MB-231 cells assessed as increase in acetylated alpha-tubulin incubated for 8 hrs by Western blot analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 4. | ALA4774031 | B | Inhibition of STAT3 in human MDA-MB-231 cells assessed as reduction in STAT-3 phosphorylation incubated for 8 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA4774032 | T | Toxicity in C57BL/6 mouse assessed death of organism at 300 mg/kg, ip observed for 24 hrs | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 6. | ALA4774033 | T | Toxicity in C57BL/6 mouse assessed death of organism at 50 mg/kg, po observed for 20 days | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 7. | ALA4774034 | B | Inhibition of recombinant human C-terminal GST-tagged full length HDAC-1 expressed in baculovirus infected in Sf9 cells using Boc-Lys (q-Ac)-AMC as substrate incubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence based assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4774035 | B | Inhibition of recombinant human C-terminal GST-tagged full length HDAC-2 expressed in baculovirus infected in Sf9 cells using Boc-Lys (q-Ac)-AMC as substrate incubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence based assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4774036 | B | Inhibition of recombinant human C-terminal GST-tagged full length HDAC-3 expressed in baculovirus infected in Sf9 cells using Boc-Lys (q-Ac)-AMC as substrate incubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence based assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4774037 | B | Inhibition of recombinant human N-terminal GST-tagged HDAC-4 (612 to end residues) expressed in baculovirus infected in Sf9 cells using Boc-Lys (q-Ac)-AMC as substrate incubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence based assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4774038 | B | Inhibition of recombinant human N-terminal GST-tagged HDAC-5 (617 to end residues) expressed in baculovirus infected in Sf9 cells using Boc-Lys (q-Ac)-AMC as substrate incubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence based assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4774039 | B | Inhibition of recombinant human N-terminal GST-tagged HDAC-5 (617 to end residues) expressed in baculovirus infected in Sf9 cells at 10 uM using Boc-Lys (q-Ac)-AMC as substrate incubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence based assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4774040 | B | Inhibition of recombinant human N-terminal GST-tagged full length HDAC-6 expressed in baculovirus infected in Sf9 cells using Boc-Lys (q-Ac)-AMC as substrate incubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence based assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4774041 | B | Inhibition of recombinant human N-terminal GST-tagged HDAC-7 (501 to end residues) expressed in baculovirus infected in Sf9 cells using Boc-Lys (q-Ac)-AMC as substrate incubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence based assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4774042 | B | Inhibition of recombinant human N-terminal GST-tagged HDAC-7 (501 to end residues) expressed in baculovirus infected in Sf9 cells at 10 uM using Boc-Lys (q-Ac)-AMC as substrate incubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence based assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4774043 | B | Inhibition of recombinant human N-terminal GST-tagged full length HDAC-8 expressed in baculovirus infected in Sf9 cells using Boc-Lys (q-Ac)-AMC as substrate incubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence based assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4774044 | B | Inhibition of recombinant human N-terminal GST-tagged HDAC-9 (548 to end residues) expressed in baculovirus infected in Sf9 cells using Boc-Lys (q-Ac)-AMC as substrate incubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence based assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4774045 | B | Inhibition of recombinant human N-terminal GST-tagged HDAC-9 (548 to end residues) expressed in baculovirus infected in Sf9 cells at 10 uM using Boc-Lys (q-Ac)-AMC as substrate incubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence based assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4774046 | B | Inhibition of recombinant human N-terminal GST-tagged HDAC-10 (1 to 482 residues) expressed in baculovirus infected in Sf9 cells using Boc-Lys (q-Ac)-AMC as substrate incubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence based assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4774047 | B | Inhibition of recombinant human N-terminal GST-tagged full length HDAC-11 expressed in baculovirus infected in Sf9 cells using Boc-Lys (q-Ac)-AMC as substrate incubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence based assay | Homo sapiens | 1 | cell-based format | Scientific Literature |
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