# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4651342 | A | Mean oral bioavailability in Swiss albino male mice at 2.5 mg/kg per compound (administered in a mixture of 5 compounds to 3 mice) assessed by LCMS/MS. | Mus musculus | 52 | organism-based format | Salvensis and LSHTM Schistosomiasis screening data | ||
2. | ALA4651343 | A | Mean AUC inf in Swiss albino male mice at 1 mg/kg per compound (administered iv in a mixture of 5 compounds to 3 mice) assessed by LCMS/MS. | Mus musculus | 55 | organism-based format | Salvensis and LSHTM Schistosomiasis screening data | ||
3. | ALA4651344 | A | Mean observed clearance in Swiss albino male mice at 1 mg/kg per compound (administered iv in a mixture of 5 compounds to 3 mice) assessed by LCMS/MS. | Mus musculus | 55 | organism-based format | Salvensis and LSHTM Schistosomiasis screening data | ||
4. | ALA4651345 | A | Mean volume of distribution at steady state in Swiss albino male mice at 1 mg/kg per compound (administered iv in a mixture of 5 compounds to 3 mice) assessed by LCMS/MS. | Mus musculus | 55 | organism-based format | Salvensis and LSHTM Schistosomiasis screening data | ||
5. | ALA4651346 | A | Mean half-life in Swiss albino male mice at 1 mg/kg per compound (administered iv in a mixture of 5 compounds to 3 mice) assessed by LCMS/MS. | Mus musculus | 55 | organism-based format | Salvensis and LSHTM Schistosomiasis screening data | ||
6. | ALA4651347 | A | Mean plasma concentration at 24h in Swiss albino male mice at 2.5 mg/kg per compound (administered orally in a mixture of 5 compounds to 3 mice) assessed by LCMS/MS. | Mus musculus | 55 | organism-based format | Salvensis and LSHTM Schistosomiasis screening data | ||
7. | ALA4651348 | A | Mean plasma concentration at 4h in Swiss albino male mice at 2.5 mg/kg per compound (administered orally in a mixture of 5 compounds to 3 mice) assessed by LCMS/MS. | Mus musculus | 55 | organism-based format | Salvensis and LSHTM Schistosomiasis screening data | ||
8. | ALA4651349 | A | Mean time to peak plasma concentration in Swiss albino male mice at 2.5 mg/kg per compound (administered orally in a mixture of 5 compounds to 3 mice) assessed by LCMS/MS. | Mus musculus | 53 | organism-based format | Salvensis and LSHTM Schistosomiasis screening data | ||
9. | ALA4651354 | P | Partition coefficient of compound between n-octanol and PBS (pH7.4) | 38 | small-molecule physicochemical format | Salvensis and LSHTM Schistosomiasis screening data | |||
10. | ALA4651355 | A | Percentage of parent compound remaining after incubation for 30 minutes with cyropreserved mouse hepatocytes at a concentration of 1uM compound and 0.5 million cells/uL, determined by LCMS | Mus musculus | 27 | tissue-based format | Salvensis and LSHTM Schistosomiasis screening data | ||
11. | ALA4651358 | A | Plasma protein binding determined at 1uM by LC-MS/MS. | Mus musculus | 10 | cell-free format | Salvensis and LSHTM Schistosomiasis screening data | ||
12. | ALA4651361 | P | Solubility at 25 degC of compound (diluted from DMSO) in PBS at pH 7.4 determined after 24h (1h sonication, 22h shaking, 1h sonication) by LCMS/MS | 60 | small-molecule physicochemical format | Salvensis and LSHTM Schistosomiasis screening data | |||
13. | ALA4651364 | F | Concentration required to kill 50% of 42 day old worms 5 days after drug treatment. | Schistosoma mansoni | 98 | organism-based format | Salvensis and LSHTM Schistosomiasis screening data | ||
14. | ALA4651365 | F | Concentration required to kill 50% of 21 day old worms 5 days after drug treatment. | Schistosoma mansoni | 262 | organism-based format | Salvensis and LSHTM Schistosomiasis screening data |