| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4731755 | B | Inhibition of human SIRT1 deacetylation activity using H3K9Ac as substrate preincubated for 15 mins in presence of NAD+ followed by substrate addition by HPLC analysis | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 2. | ALA4731756 | B | Inhibition of human SIRT2 deacetylation activity using H3K9Ac as substrate preincubated for 15 mins in presence of NAD+ by HPLC analysis | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 3. | ALA4731757 | B | Inhibition of human SIRT2 deacetylation activity using H3K9Ac as substrate in presence of NAD+ by HPLC analysis | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 4. | ALA4731758 | B | Inhibition of human SIRT2 defatty-acylation activity using peptide substrate preincubated in presence of NAD+ followed by substrate addition by HPLC analysis | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 5. | ALA4731759 | B | Inhibition of human SIRT2 defatty-acylation activity using peptide substrate in presence of NAD+ by HPLC analysis | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 6. | ALA4731760 | B | Inhibition of human SIRT3 deacetylation activity using H3K9Ac as substrate preincubated for 15 mins in presence of NAD+ followed by substrate addition by HPLC analysis | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 7. | ALA4731761 | B | Inhibition of human SIRT5 deacetylation activity using H3K9Ac as substrate preincubated for 15 mins in presence of NAD+ followed by substrate addition by HPLC analysis | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 8. | ALA4731762 | B | Inhibition of human SIRT6 deacetylation activity using H3K9Ac as substrate preincubated for 15 mins in presence of NAD+ followed by substrate addition by HPLC analysis | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 9. | ALA4731763 | B | Selectivity ratio of IC50 for inhibition of human SIRT1 deacetylation activity to IC50 for inhibition of human SIRT2 deacetylation activity | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 10. | ALA4731764 | B | Protac activity at CRBN/SIRT1 in human MCF7 cells assessed as SIRT1 degradation at 5 to 10 uM after 48 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA4731765 | B | Protac activity at CRBN/SIRT1 in human BT549 cells assessed as SIRT1 degradation at 5 to 10 uM after 48 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA4731766 | B | Protac activity at CRBN/SIRT2 in human MCF7 cells assessed as SIRT2 degradation at 5 to 10 uM after 48 hrs by immunoblot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 13. | ALA4731767 | B | Protac activity at CRBN/SIRT2 in human BT549 cells assessed as SIRT2 degradation at 5 to 10 uM after 48 hrs by immunoblot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 14. | ALA4731768 | B | Protac activity at CRBN/SIRT3 in human MCF7 cells assessed as SIRT3 degradation at 5 to 10 uM after 48 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA4731769 | B | Protac activity at CRBN/SIRT3 in human BT549 cells assessed as SIRT3 degradation at 5 to 10 uM after 48 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA4731770 | B | Protac activity at CRBN/SIRT2 in human MDA-MB-231 cells assessed as SIRT2 degradation after 48 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA4731771 | B | Protac activity at CRBN/SIRT2 in human MDA-MB-468 cells assessed as SIRT2 degradation after 48 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 18. | ALA4731773 | B | Protac activity at CRBN/SIRT2 in human MCF7 cells assessed as SIRT2 degradation at 10 uM by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 19. | ALA4731775 | B | Protac activity at CRBN/SIRT2 in human MCF7 cells assessed as SIRT2 degradation at 25 uM by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature |
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