| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4770538 | A | Metabolic stability in rat liver microsomes assessed as parent compound remaining at 10 uM preincubated for 10 mins followed by NADPH addition and measured after 30 mins | Rattus norvegicus | 21 | microsome format | Scientific Literature | ||
| 2. | ALA4770539 | B | Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 3. | ALA4770540 | B | Displacement of [3H]-8-OH-DPAT from human 5-HT1A expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 4. | ALA4770541 | A | Metabolic stability in rat liver microsomes assessed as half life at 10 uM preincubated for 10 mins followed by NADPH addition and measured after 30 mins | Rattus norvegicus | 10 | microsome format | Scientific Literature | ||
| 5. | ALA4770542 | A | Metabolic stability in rat liver microsomes assessed as apparent intrinsic clearance at 10 uM preincubated for 10 mins followed by NADPH addition and measured after 30 mins | Rattus norvegicus | 10 | microsome format | Scientific Literature | ||
| 6. | ALA4770543 | A | Metabolic stability in rat hepatocytes assessed as half life at 10 uM measured up to 120 mins | Rattus norvegicus | 10 | cell-based format | Scientific Literature | ||
| 7. | ALA4770544 | A | Protein binding in human serum albumin assessed as unbound fraction at 10 uM by TRANSIL assay | Homo sapiens | 10 | single protein format | Scientific Literature | ||
| 8. | ALA4770545 | A | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 9. | ALA4770546 | A | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 10. | ALA4770547 | A | Cytotoxicity against human SH-SY5Y cells after 48 hrs by MTT assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 11. | ALA4770548 | B | Inhibition of human ERG expressed in CHO cells by patch clamp method | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 12. | ALA4770549 | A | Inhibition of human Nav1.5 expressed in HEK293T cells at 0.1 to 10 Hz frequency at -120 mV holding potential by whole cell patch clamp electrophysiology assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 13. | ALA4770550 | B | Agonist activity at 5HT7 receptor in C57BL/6 mouse hippocampal neurons assessed as reversal of DHPG induced mGluR-dependent long-term depression by measuring excitatory postsynaptic current at -70 mV holding potential at 100 nM pretreated with DHPG for 5 mins after DHPG washout compound addition measured after 40 mins by whole cell patch clamp assay (Rvb = 67.7 +/- 8 %) | Mus musculus | 2 | tissue-based format | Scientific Literature | ||
| 14. | ALA4770551 | F | Effect on behavioral changes in Fmr1 KO C57BL/6J mouse assessed as reduction in digging behavior under nesting out condition at 3 mg/kg, ip after 30 mins by nesting removal test | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4770552 | F | Effect on locomotor activity in Fmr1 KO C57BL/6J mouse at 3 mg/kg, ip measured after 30 mins under nesting out condition | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4770553 | F | Effect on locomotor activity in wild type C57BL/6J mouse at 3 mg/kg, ip measured after 30 mins under nesting out condition | Mus musculus | 1 | organism-based format | Scientific Literature |
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