| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4773454 | A | Protein binding in mouse plasma at 1 uM | Mus musculus | 1 | ALA4765416 | cell-free format | Scientific Literature | |
| 2. | ALA4773455 | A | Intrinsic clearance in rat liver microsomes at 1 uM peincubated for 10 mins followed by NADPH addition and measured 60 mins by LC-MS/MS analysis | Rattus norvegicus | 16 | ALA4765416 | microsome format | Scientific Literature | |
| 3. | ALA4773456 | A | Half life in rat liver microsomes at 1 uM peincubated for 10 mins followed by NADPH addition and measured 60 mins by LC-MS/MS analysis | Rattus norvegicus | 16 | ALA4765416 | microsome format | Scientific Literature | |
| 4. | ALA4773457 | B | Inhibition of APC-conjugated anti-human CXCR4 clone 12G5 binding to CXCR4 in human HPBALL cells measured after 3 hrs by FACS analysis | Homo sapiens | 10 | ALA4765416 | cell-based format | Scientific Literature | |
| 5. | ALA4773458 | F | Antagonist activity at CXCR4 in human CD4-positive T cells assessed as inhibition of CXCL12-induced cytosolic calcium flux preincubated for 20 mins followed by CXCL12 addition by calcium 4 dye based FLIPR TETRA analysis | Homo sapiens | 15 | ALA4765416 | cell-based format | Scientific Literature | |
| 6. | ALA4773459 | P | 1-Octanol/water partition coefficient, log P of compound at pH 7.4 measured after 24 hrs by shake flask method | 1 | ALA4765416 | small-molecule physicochemical format | Scientific Literature | ||
| 7. | ALA4773460 | P | Dissociation constant, basic pKa of compound by titration method | 1 | ALA4765416 | small-molecule physicochemical format | Scientific Literature | ||
| 8. | ALA4773462 | F | Antagonist activity at CXCR1 (unknown origin) expressed in HEK293 cells assessed as suppression of IL-8-induced inhibition of forskolin-induced cAMP formation up to 10 uM preincubated for 15 mins followed by forskolin and IL-8 stimulation and measured after 15 mins by cAMP-d2 and Eu-Anti-cAMP based fluorescence assay | Homo sapiens | 1 | ALA4765416 | cell-based format | Scientific Literature | |
| 9. | ALA4773463 | F | Antagonist activity at CCR6 in human CD4-positive T cells assessed as inhibition of CCL20-induced cytosolic calcium flux up to 10 uM by calcium 4 dye based FLIPR TETRA analysis | Homo sapiens | 1 | ALA4765416 | cell-based format | Scientific Literature | |
| 10. | ALA4773464 | B | Antagonist activity at CXCR4 in human MDA-MB-231 cells assessed as inhibition of CXCL12-induced cell migration at 100 nM measured after 24 hrs by crystal violet staining based matrigel invasion assay | Homo sapiens | 2 | ALA4765416 | cell-based format | Scientific Literature | |
| 11. | ALA4773465 | A | Cytotoxicity against mouse L929 cells assessed as reduction in cell proliferation up to 1000 nM by ATP-based celltiter-glo luminescent assay | Mus musculus | 1 | ALA4765416 | cell-based format | Scientific Literature | |
| 12. | ALA4773466 | A | Cytotoxicity against MEF cells assessed as reduction in cell proliferation up to 1000 nM by ATP-based celltiter-glo luminescent assay | Mus musculus | 1 | ALA4765416 | cell-based format | Scientific Literature | |
| 13. | ALA4773467 | A | Cytotoxicity against human Hepa1-6 cells assessed as reduction in cell proliferation up to 1000 nM by ATP-based celltiter-glo luminescent assay | Homo sapiens | 1 | ALA4765416 | cell-based format | Scientific Literature | |
| 14. | ALA4773468 | A | Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell proliferation up to 1000 nM by ATP-based celltiter-glo luminescent assay | Homo sapiens | 1 | ALA4765416 | cell-based format | Scientific Literature | |
| 15. | ALA4773469 | A | Inhibition of CYP1A2 in human liver microsomes at 10 uM using phenacetin as substrate preincubated for 10 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4765416 | microsome format | Scientific Literature | |
| 16. | ALA4773470 | A | Inhibition of CYP2C9 in human liver microsomes at 10 uM using tolbutamide as substrate preincubated for 10 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4765416 | microsome format | Scientific Literature | |
| 17. | ALA4773471 | A | Inhibition of CYP2C19 in human liver microsomes at 10 uM using S-mephenytoin as substrate preincubated for 10 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4765416 | microsome format | Scientific Literature | |
| 18. | ALA4773472 | A | Inhibition of CYP2D6 in human liver microsomes at 10 uM using dextromethorphan as substrate preincubated for 10 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4765416 | microsome format | Scientific Literature | |
| 19. | ALA4773473 | A | Inhibition of CYP3A4 in human liver microsomes at 10 uM using midazolam as substrate preincubated for 10 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4765416 | microsome format | Scientific Literature | |
| 20. | ALA4773474 | A | Inhibition of CYP3A4 in human liver microsomes at 10 uM using testosterone as substrate preincubated for 10 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4765416 | microsome format | Scientific Literature |
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