| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4669220 | Binding | Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay | Homo sapiens | 28 | ALA4665717 | cell-based format | Scientific Literature | |
| 2. | ALA4669222 | Functional | Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay | Homo sapiens | 20 | ALA4665717 | cell-based format | Scientific Literature | |
| 3. | ALA4669223 | ADME | Metabolic stability in human liver microsomes assessed as intrinsic clearance at 1 uM in presence of NADPH by HPLC-UV analysis | Homo sapiens | 20 | ALA4665717 | microsome format | Scientific Literature | |
| 4. | ALA4669224 | ADME | Metabolic stability in Wistar rat liver microsomes assessed as intrinsic clearance at 1 uM in presence of NADPH by HPLC-UV analysis | Rattus norvegicus | 20 | ALA4665717 | microsome format | Scientific Literature | |
| 5. | ALA4669225 | ADME | Metabolic stability in NMRI mouse liver microsomes assessed as intrinsic clearance at 1 uM in presence of NADPH by HPLC-UV analysis | Mus musculus | 20 | ALA4665717 | microsome format | Scientific Literature | |
| 6. | ALA4669227 | ADME | Apparent permeability across apical to basolateral side in vinblastine-treated human Caco-2 cells at 10 uM by HPLC-UV analysis | Homo sapiens | 5 | ALA4665717 | tissue-based format | Scientific Literature | |
| 7. | ALA4669229 | ADME | Efflux ratio of Apparent permeability across apical to basolateral side in human Caco-2 cells expressing P-glycoprotein at 10 uM by HPLC-UV analysis | Homo sapiens | 5 | ALA4665717 | cell-based format | Scientific Literature | |
| 8. | ALA4669232 | Binding | Inhibition of human ERG by QPatch HTX automated patch clamp system | Homo sapiens | 3 | ALA4665717 | assay format | Scientific Literature | |
| 9. | ALA4669234 | Binding | Displacement of [3H]AVP from human V2a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay | Homo sapiens | 1 | ALA4665717 | cell-based format | Scientific Literature | |
| 10. | ALA4669235 | Functional | Anti-depression activity in mouse assessed as inhibition of oxytocin-induced scratching at 30 mg/kg, ip administered before oxytocin stimulation and measured after 1 hr | Mus musculus | 2 | ALA4665717 | organism-based format | Scientific Literature | |
| 11. | ALA5042986 | Physicochemical | Kinetic solubility of compound in PBS at pH 7.4 incubated for 2 hrs by HPLC-MS analysis | 4 | ALA5042479 | small-molecule physicochemical format | Scientific Literature | ||
| 12. | ALA5042987 | Binding | Displacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assay | Homo sapiens | 16 | ALA5042479 | cell membrane format | Scientific Literature | |
| 13. | ALA5042988 | Functional | Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate reader | Homo sapiens | 10 | ALA5042479 | cell-based format | Scientific Literature | |
| 14. | ALA5042989 | Binding | Displacement of [3H]-arginine-vasopressin from human V2 receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assay | Homo sapiens | 7 | ALA5042479 | cell membrane format | Scientific Literature | |
| 15. | ALA5042990 | Binding | Selectivity ratio of Ki for human V2 receptor expressed in human 1321N1 cell membranes to Ki for human V1A receptor expressed in human 1321N1 cell membranes | Homo sapiens | 4 | ALA5042479 | cell-based format | Scientific Literature | |
| 16. | ALA5042991 | ADME | Intrinsic clearance in human liver microsomes in presence of reduced NADPH | Homo sapiens | 4 | ALA5042479 | microsome format | Scientific Literature | |
| 17. | ALA5042992 | ADME | Intrinsic clearance in rat liver microsomes in presence of reduced NADPH | Rattus norvegicus | 4 | ALA5042479 | microsome format | Scientific Literature | |
| 18. | ALA5042993 | ADME | Intrinsic clearance in mouse liver microsomes in presence of reduced NADPH | Mus musculus | 4 | ALA5042479 | microsome format | Scientific Literature | |
| 19. | ALA5042994 | ADME | Apparent permeability across apical to basolateral side in mouse Caco-2 cells | Homo sapiens | 4 | ALA5042479 | cell-based format | Scientific Literature | |
| 20. | ALA5042995 | ADME | Permeability directional ratio in mouse Caco-2 cells | Homo sapiens | 4 | ALA5042479 | cell-based format | Scientific Literature |
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