# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4669220 | B | Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
2. | ALA4669222 | F | Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric calcium assay | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
3. | ALA4669223 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance at 1 uM in presence of NADPH by HPLC-UV analysis | Homo sapiens | 20 | microsome format | Scientific Literature | ||
4. | ALA4669224 | A | Metabolic stability in Wistar rat liver microsomes assessed as intrinsic clearance at 1 uM in presence of NADPH by HPLC-UV analysis | Rattus norvegicus | 20 | microsome format | Scientific Literature | ||
5. | ALA4669225 | A | Metabolic stability in NMRI mouse liver microsomes assessed as intrinsic clearance at 1 uM in presence of NADPH by HPLC-UV analysis | Mus musculus | 20 | microsome format | Scientific Literature | ||
6. | ALA4669227 | A | Apparent permeability across apical to basolateral side in vinblastine-treated human Caco-2 cells at 10 uM by HPLC-UV analysis | Homo sapiens | 5 | tissue-based format | Scientific Literature | ||
7. | ALA4669229 | A | Efflux ratio of Apparent permeability across apical to basolateral side in human Caco-2 cells expressing P-glycoprotein at 10 uM by HPLC-UV analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
8. | ALA4669232 | B | Inhibition of human ERG by QPatch HTX automated patch clamp system | Homo sapiens | 3 | assay format | Scientific Literature | ||
9. | ALA4669234 | B | Displacement of [3H]AVP from human V2a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
10. | ALA4669235 | F | Anti-depression activity in mouse assessed as inhibition of oxytocin-induced scratching at 30 mg/kg, ip administered before oxytocin stimulation and measured after 1 hr | Mus musculus | 2 | organism-based format | Scientific Literature | ||
11. | ALA5042986 | P | Kinetic solubility of compound in PBS at pH 7.4 incubated for 2 hrs by HPLC-MS analysis | 4 | small-molecule physicochemical format | Scientific Literature | |||
12. | ALA5042987 | B | Displacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assay | Homo sapiens | 16 | cell membrane format | Scientific Literature | ||
13. | ALA5042988 | F | Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate reader | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
14. | ALA5042989 | B | Displacement of [3H]-arginine-vasopressin from human V2 receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assay | Homo sapiens | 7 | cell membrane format | Scientific Literature | ||
15. | ALA5042990 | B | Selectivity ratio of Ki for human V2 receptor expressed in human 1321N1 cell membranes to Ki for human V1A receptor expressed in human 1321N1 cell membranes | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
16. | ALA5042991 | A | Intrinsic clearance in human liver microsomes in presence of reduced NADPH | Homo sapiens | 4 | microsome format | Scientific Literature | ||
17. | ALA5042992 | A | Intrinsic clearance in rat liver microsomes in presence of reduced NADPH | Rattus norvegicus | 4 | microsome format | Scientific Literature | ||
18. | ALA5042993 | A | Intrinsic clearance in mouse liver microsomes in presence of reduced NADPH | Mus musculus | 4 | microsome format | Scientific Literature | ||
19. | ALA5042994 | A | Apparent permeability across apical to basolateral side in mouse Caco-2 cells | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
20. | ALA5042995 | A | Permeability directional ratio in mouse Caco-2 cells | Homo sapiens | 4 | cell-based format | Scientific Literature |