# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4685843 | B | Inhibition of class 1 HDAC in human HeLa cell nuclear extract using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by fluorescence assay | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
2. | ALA4685844 | B | Inhibition of recombinant human N-terminal GST-tagged HDAC7 (518 to end residues) expressed in baculovirus infected Sf9 cells using fluorogenic HDAC 2A substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by fluorescence assay | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
3. | ALA4685845 | B | Inhibition of recombinant human N-terminal GST-tagged/C-terminal His-tagged HDAC4 (627 to 1084 residues) expressed in baculovirus expression system using Boc-Lys(TFA)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by fluorescence assay | Homo sapiens | 13 | assay format | Scientific Literature | ||
4. | ALA4685846 | B | Inhibition of recombinant human C-terminal His-tagged HDAC5 (656 to 1122 residues) expressed in baculovirus infected Sf9 insect cells using fluorogenic HDAC 2A substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by fluorescence assay | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
5. | ALA4685847 | B | Inhibition of recombinant human C-terminal His-tagged HDAC9 (604 to 1066 residues) expressed in baculovirus infected Sf9 cells using fluorogenic HDAC 2A substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by fluorescence assay | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
6. | ALA4685848 | B | Inhibition of recombinant human full-length N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 insect cells using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by fluorescence assay | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
7. | ALA4685849 | B | Inhibition of amyloid beta (1 to 42) (unknown origin) self aggregation after 24 hrs by thioflavin-T fluorescence method | Homo sapiens | 11 | single protein format | Scientific Literature | ||
8. | ALA4685850 | B | Disaggregation of self-induced amyloid beta (1 to 42) (unknown origin) preformed fibrils at 10 uM measured after 24 hrs by thioflavin-T fluorescence assay relative to control | Homo sapiens | 11 | single protein format | Scientific Literature | ||
9. | ALA4685851 | B | Inhibition of recombinant human C-terminal 6His-tagged AChE (Glu32 to Leu614 residues) expressed in CHO cells using acetylthiocholine iodide as substrate preincubated for 5 mins measured after 15 mins by DTNB reagent based assay | Homo sapiens | 10 | cell-based format | Scientific Literature |