# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4742483 | B | Inhibition of CDK7/Cyclin H/MAT1 (unknown origin) using 5-FAM-CDK7tide peptide substrate incubated for 35 mins | Homo sapiens | 277 | protein complex format | Patent Bioactivity Data | ||
2. | ALA4742484 | B | Inhibition of CDK2/Cyclin E (unknown origin) using 5-FAM-CDK7tide substrate incubated for 35 mins | Homo sapiens | 277 | protein complex format | Patent Bioactivity Data | ||
3. | ALA4742485 | B | Inhibition of CDK12 (686 to 1082 residues) /Cyclin K (unknown origin) using 5-FAM-CDK9tide peptide substrate incubated for 3 hrs | Homo sapiens | 277 | protein complex format | Patent Bioactivity Data | ||
4. | ALA4742486 | B | Inhibition of CDK9/Cyclin T1 (unknown origin) using 5-FAM-CDK9tide peptide substrate incubated for 15 mins | Homo sapiens | 277 | protein complex format | Patent Bioactivity Data | ||
5. | ALA4742487 | F | Inhibition of cell proliferation of human A673 cells incubated for 72 hrs by CyQUANT assay | Homo sapiens | 277 | cell-based format | Patent Bioactivity Data | ||
6. | ALA4742488 | F | Inhibition of cell proliferation of human HCC70 cells incubated for 72 hrs by CyQUANT assay | Homo sapiens | 277 | cell-based format | Patent Bioactivity Data | ||
7. | ALA5043156 | A | Oral bioavailability in CD-1 mouse 5 mg/kg measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 12 | organism-based format | Scientific Literature | ||
8. | ALA5043157 | A | Unbound clearance in CD-1 mouse at 1 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 14 | organism-based format | Scientific Literature | ||
9. | ALA5043158 | A | Apparent permeability across apical to basolateral side in MDCK cells | Canis lupus familiaris | 13 | cell-based format | Scientific Literature | ||
10. | ALA5043159 | A | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance | Mus musculus | 15 | microsome format | Scientific Literature | ||
11. | ALA5043160 | P | Lipophilicity, log D of compound | 15 | small-molecule physicochemical format | Scientific Literature | |||
12. | ALA5043162 | B | Inhibition of CDK2/cyclin E1 (unknown origin) using 5-FAM-labeled peptide as substrate in presence of ATP by mobility shift assay | Homo sapiens | 15 | protein complex format | Scientific Literature | ||
13. | ALA5043163 | F | Antiproliferative activity against human HCC70 cells incubated for 72 hrs by Celltiter-glo assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
14. | ALA5043164 | B | Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origin) expressed in baculovirus infected Sf9 cells by Surface plasmon resonance assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
15. | ALA5043165 | B | Inhibition of CDK9/cyclin T1 (unknown origin) using 5-FAM-labeled peptide as substrate in presence of ATP by mobility shift assay | Homo sapiens | 15 | protein complex format | Scientific Literature | ||
16. | ALA5043166 | B | Inhibition of CDK12/cyclin K (unknown origin) using 5-FAM-labeled peptide as substrate in presence of ATP by mobility shift assay | Homo sapiens | 15 | protein complex format | Scientific Literature | ||
17. | ALA5043167 | B | Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origin) expressed in baculovirus infected Sf9 cells assessed as binding constant (Koff) by Surface plasmon resonance assay | Homo sapiens | 4 | cell-based format | Scientific Literature |