# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4733830 | Functional | Antiproliferative activity against human Rh30 cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay | Homo sapiens | 16 | ALA4732078 | cell-based format | Scientific Literature | |
2. | ALA4733831 | Binding | Inhibition of human PI3Kalpha using PIP2 as substrate in presence of ATP measured after 30 mins by HTRF assay | Homo sapiens | 15 | ALA4732078 | single protein format | Scientific Literature | |
3. | ALA4733834 | Binding | Inhibition of human recombinant c-Raf Y340D/Y341D mutant (306 to end residues) using inactive MEK1 as substrate at 10 uM incubated for 40 mins in presence of [gamma33P-ATP] by radiometric scintillation counting analysis | Homo sapiens | 1 | ALA4732078 | single protein format | Scientific Literature | |
4. | ALA4733835 | Binding | Inhibition of human recombinant c-Raf Y340D/Y341D mutant (306 to end residues) using inactive MEK1 as substrate incubated for 40 mins in presence of [gamma33P-ATP] by radiometric scintillation counting analysis | Homo sapiens | 1 | ALA4732078 | single protein format | Scientific Literature | |
5. | ALA4733836 | Binding | Inhibition of human PI3K p110alpha E545K mutant/p85alpha using PIP2 as substrate incubated for 40 mins in presence of ATP by HTRF assay | Homo sapiens | 2 | ALA4732078 | assay format | Scientific Literature | |
6. | ALA4733837 | Binding | Inhibition of human PI3K p110alpha H1047R mutant/p85alpha using PIP2 as substrate incubated for 40 mins in presence of ATP by HTRF assay | Homo sapiens | 2 | ALA4732078 | assay format | Scientific Literature | |
7. | ALA4733838 | Binding | Inhibition of human PI3K p110beta/p85alpha using PIP2 as substrate incubated for 40 mins in presence of ATP measured after 40 mins by HTRF assay | Homo sapiens | 2 | ALA4732078 | protein complex format | Scientific Literature | |
8. | ALA4733839 | Binding | Inhibition of human PI3Kgamma R459Q mutant using PIP2 as substrate in presence of ATP measured after 40 mins by HTRF assay | Homo sapiens | 2 | ALA4732078 | assay format | Scientific Literature | |
9. | ALA4733840 | Binding | Inhibition of human PI3K p110delta/p85alpha using PIP2 as substrate in presence of ATP measured after 40 mins by HTRF assay | Homo sapiens | 2 | ALA4732078 | protein complex format | Scientific Literature | |
10. | ALA4733841 | Binding | Inhibition of PI3Kalpha (unknown origin) transfected in human Rh30 cells assessed as reduction in AKT phosphorylation at Ser473 at 14 nM by western blot analysis | Homo sapiens | 1 | ALA4732078 | cell-based format | Scientific Literature | |
11. | ALA4733842 | Binding | Inhibition of PI3Kalpha in human U87MG cells assessed as reduction in rhIGF1-stimulated AKT phosphorylation at Ser473 treated for 1 hr followed by incubation with IGF1 for 10 mins by western blot analysis | Homo sapiens | 1 | ALA4732078 | cell-based format | Scientific Literature | |
12. | ALA4733843 | Binding | Inhibition of PI3Kalpha in human U87MG cells assessed as reduction in rhIGF1-stimulated AKT phosphorylation at Thr308 treated for 1 hr followed by incubation with IGF1 for 10 mins by western blot analysis | Homo sapiens | 1 | ALA4732078 | cell-based format | Scientific Literature | |
13. | ALA4733844 | Binding | Inhibition of PI3Kalpha in human Rh30 cells assessed as reduction in rhIGF1-stimulated AKT phosphorylation at Ser473 treated for 1 hr followed by incubation with IGF1 for 10 mins by western blot analysis | Homo sapiens | 1 | ALA4732078 | cell-based format | Scientific Literature | |
14. | ALA4733845 | Binding | Inhibition of PI3Kalpha in human Rh30 cells assessed as reduction in rhIGF1-stimulated AKT phosphorylation at Thr308 treated for 1 hr followed by incubation with IGF1 for 10 mins by western blot analysis | Homo sapiens | 1 | ALA4732078 | cell-based format | Scientific Literature | |
15. | ALA4733846 | Functional | Antiproliferative activity against human BT-474 cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay | Homo sapiens | 2 | ALA4732078 | cell-based format | Scientific Literature | |
16. | ALA4733847 | Functional | Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay | Homo sapiens | 2 | ALA4732078 | cell-based format | Scientific Literature | |
17. | ALA4733848 | Functional | Antiproliferative activity against human T47D cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay | Homo sapiens | 2 | ALA4732078 | cell-based format | Scientific Literature | |
18. | ALA4733849 | Functional | Antiproliferative activity against human SK-OV-3 cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay | Homo sapiens | 2 | ALA4732078 | cell-based format | Scientific Literature | |
19. | ALA4733850 | Functional | Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay | Homo sapiens | 2 | ALA4732078 | cell-based format | Scientific Literature | |
20. | ALA4733851 | Functional | Antiproliferative activity against human HCC1954 cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay | Homo sapiens | 2 | ALA4732078 | cell-based format | Scientific Literature |