| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4724651 | F | Antiproliferative activity against human TMD8 cells harboring MYD88 L265P mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 2. | ALA4724653 | F | Antiproliferative activity against human OCILY10 cells harboring MYD88 L265P mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 3. | ALA4724654 | B | Protac activity at CRBN/IRAK4 in human TMD8 cells assessed as inhibition of NF-kappaB p65 phosphorylation by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4724655 | B | Protac activity at CRBN/IRAK4 in human OCILY10 cells assessed as inhibition of NF-kappaB p65 phosphorylation by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4724656 | B | Protac activity at CRBN/IRAK4 in human TMD8 cells assessed as inhibition of IKKalpha/beta phosphorylation by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4724657 | B | Protac activity at CRBN/IRAK4 in human OCILY10 cells assessed as inhibition of IKKalpha/beta phosphorylation by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4724658 | B | Protac activity at CRBN/IRAK4 in human TMD8 cells assessed as inhibition of IRAK4 phosphorylation by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4724659 | B | Protac activity at CRBN/IRAK4 in human OCILY10 cells assessed as inhibition of IRAK4 phosphorylation by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4724660 | B | Protac activity at CRBN/IRAK4 in human TMD8 cells harboring MYD88 L265P mutant assessed as induction of IRAK4 degradation at 1 uM in presence of IRAK4 inhibitor, Methyl 4-(5-ethoxy-1-methyl-6-(6-(trifluoromethyl)picolinamido)-1H-benzo[d]imidazol-2-yl)-2,2-dimethylbutanoate by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4724661 | B | Protac activity at CRBN/IRAK4 in human OCILY10 cells harboring MYD88 L265P mutant assessed as induction of IRAK4 degradation at 1 uM in presence of IRAK4 inhibitor, Methyl 4-(5-ethoxy-1-methyl-6-(6-(trifluoromethyl)picolinamido)-1H-benzo[d]imidazol-2-yl)-2,2-dimethylbutanoate by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4724662 | B | Protac activity at CRBN/IRAK4 in human TMD8 cells harboring MYD88 L265P mutant assessed as induction of IRAK4 degradation at 1 uM in presence of CRBN recruiter, pomalidomide by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4724663 | B | Protac activity at CRBN/IRAK4 in human OCILY10 cells harboring MYD88 L265P mutant assessed as induction of IRAK4 degradation at 1 uM in presence of CRBN recruiter, pomalidomide by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4724664 | B | Protac activity at CRBN/IRAK4 in human TMD8 cells harboring MYD88 L265P mutant assessed as induction of IRAK4 degradation at 1 uM pretreated with proteasome inhibitor, MG132 for 2 hrs followed by compound addition by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4724665 | B | Protac activity at CRBN/IRAK4 in human OCILY10 cells harboring MYD88 L265P mutant assessed as induction of IRAK4 degradation at 1 uM pretreated with proteasome inhibitor, MG132 for 2 hrs followed by compound addition by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4724666 | B | Protac activity at CRBN/IRAK4 in human TMD8 cells harboring MYD88 L265P mutant assessed as induction of IRAK4 degradation by measuring reduction in IRAK4 protein level at 1 uM by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4724667 | B | Protac activity at CRBN/IRAK4 in human OCILY10 cells harboring MYD88 L265P mutant assessed as induction of IRAK4 degradation by measuring reduction in IRAK4 protein level at 1 uM by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4724668 | B | Protac activity at CRBN/IRAK4 in human TMD8 cells harboring MYD88 L265P mutant assessed as induction of IRAK4 degradation by measuring reduction in IRAK4 protein level incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4724669 | B | Protac activity at CRBN/IRAK4 in human OCILY10 cells harboring MYD88 L265P mutant assessed as induction of IRAK4 degradation by measuring reduction in IRAK4 protein level incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4724670 | B | Protac activity at CRBN/IRAK4 in human TMD8 cells harboring MYD88 L265P mutant assessed as induction of IRAK4 degradation by measuring reduction in IRAK4 protein level at 1 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 20. | ALA4724671 | B | Protac activity at CRBN/IRAK4 in human OCILY10 cells harboring MYD88 L265P mutant assessed as induction of IRAK4 degradation by measuring reduction in IRAK4 protein level at 1 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 9 | cell-based format | Scientific Literature |
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