| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4768895 | B | Inhibition of LSD1 (unknown origin) incubated for 90 mins by fluorescence based assay | Homo sapiens | 26 | single protein format | Scientific Literature | ||
| 2. | ALA4768896 | F | Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
| 3. | ALA4822805 | B | Agonist activity at ERalpha (unknown origin) expressed in human HEK293T cells assessed as transcriptional activities by measuring ERE driven reporter gene expression measured after 24 hrs by dual luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4822807 | B | Agonist activity at ERalpha (unknown origin) expressed in human HEK293T cells assessed as transcriptional activities by measuring ERE driven reporter gene expression measured after 24 hrs by dual luciferase reporter gene assay relative to 17beta-estradiol | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
| 5. | ALA4822808 | B | Agonist activity at ERbeta (unknown origin) expressed in human HEK293T cells assessed as transcriptional activities by measuring ERE driven reporter gene expression measured after 24 hrs by dual luciferase reporter gene assay relative to 17beta-estradiol | Homo sapiens | 23 | cell-based format | Scientific Literature | ||
| 6. | ALA4822809 | B | Antagonist activity at ERalpha (unknown origin) expressed in human HEK293T cells assessed as inhibition of 17beta-estradiol-induced transcriptional activities by measuring ERE driven reporter gene expression measured after 24 hrs by dual luciferase reporter gene assay | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 7. | ALA4822810 | B | Antagonist activity at ERbeta (unknown origin) expressed in human HEK293T cells assessed as inhibition of 17beta-estradiol-induced transcriptional activities by measuring ERE driven reporter gene expression measured after 24 hrs by dual luciferase reporter gene assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 8. | ALA4822811 | B | Antagonist activity at ERalpha (unknown origin) expressed in human HEK293T cells assessed as inhibition of 17beta-estradiol-induced transcriptional activities by measuring ERE driven reporter gene expression measured after 24 hrs by dual luciferase reporter gene assay relative to 17beta-estradiol | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 9. | ALA4822812 | B | Antagonist activity at human ERbeta expressed in human HEK293T cells assessed as inhibition of 17beta-estradiol-induced transcriptional activities by measuring ERE driven reporter gene expression measured after 24 hrs by dual luciferase reporter gene assay relative to 17beta-estradiol | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
| 10. | ALA5167811 | B | Relative binding affinity to human ERalpha measured after 2 hrs by competitive fluorometric binding assay relative to estradiol | Homo sapiens | 24 | single protein format | Scientific Literature | ||
| 11. | ALA5167812 | B | Relative binding affinity to human ERbeta measured after 2 hrs by competitive fluorometric binding assay relative to estradiol | Homo sapiens | 24 | single protein format | Scientific Literature | ||
| 12. | ALA5167813 | B | Selectivity ratio of relative binding affinity for human ERalpha to relative binding affinity for human ERbeta | Homo sapiens | 24 | assay format | Scientific Literature | ||
| 13. | ALA5167814 | F | Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by Cell Counting Kit-8 assay | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
| 14. | ALA5167815 | F | Antiproliferative activity against tamoxifen-resistant human LCC2 cells assessed as reduction in cell viability measured after 72 hrs by Cell Counting Kit-8 assay | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
| 15. | ALA5167816 | F | Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 72 hrs by Cell Counting Kit-8 assay | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
| 16. | ALA5167817 | T | Antiproliferative activity against human MCF-10A cells assessed as reduction in cell viability measured after 72 hrs by Cell Counting Kit-8 assay | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
| 17. | ALA5167818 | T | Selectivity index, ratio of IC50 for human MCF-10A cells to IC50 for human MCF-7 cells | Homo sapiens | 24 | assay format | Scientific Literature | ||
| 18. | ALA5167871 | F | Induction of ROS production in human MCF7 cells at 20 uM measured after 48 hrs by DCFH-DA staining based confocal laser scanning microscopic method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA5167872 | F | Induction of ROS production in tamoxifen-resistant human LCC2 cells at 20 uM measured after 48 hrs by DCFH-DA staining based confocal laser scanning microscopic method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA5167875 | F | Induction of apoptosis in human MCF7 cells at 20 uM incubated for 48 hrs by annexin V-FITC staining based flow cytometry | Homo sapiens | 1 | cell-based format | Scientific Literature |
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