# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3532587 | ADME | Inhibition of OATP1B1 (unknown origin) expressed in HEK293 cells assessed as reduction of [3H]estradiol-17beta-glucuronide uptake at 10 uM after 3 mins by beta-counting | Homo sapiens | 6 | ALA3526004 | cell-based format | Scientific Literature | |
2. | ALA3529886 | ADME | Inhibition of OATP2B1 (unknown origin) expressed in MDCK2 cells assessed as reduction of [3H]estrone-3-sulfate uptake at 10 uM after 3 mins by beta-counting | Homo sapiens | 6 | ALA3526004 | cell-based format | Scientific Literature | |
3. | ALA3529887 | ADME | Inhibition of OATP1B1 (unknown origin) expressed in HEK293 cells assessed as reduction of [3H]estradiol-17beta-glucuronide uptake after 3 mins by beta-counting | Homo sapiens | 3 | ALA3526004 | cell-based format | Scientific Literature | |
4. | ALA3529888 | ADME | Inhibition of OATP1B3 (unknown origin) expressed in HEK293 cells assessed as reduction of [3H]estradiol-17beta-glucuronide uptake after 3 mins by beta-counting | Homo sapiens | 3 | ALA3526004 | cell-based format | Scientific Literature | |
5. | ALA3529889 | ADME | Inhibition of OATP2B1 (unknown origin) expressed in MDCK2 cells assessed as reduction of [3H]estrone-3-sulfate uptake after 3 mins by beta-counting | Homo sapiens | 3 | ALA3526004 | cell-based format | Scientific Literature | |
6. | ALA875235 | ADME | Disassociation constant (KI) was obtained from Cheng and Prusoff equation for quercetin trypsin complex | 7 | ALA1130430 | assay format | Scientific Literature | ||
7. | ALA817756 | Binding | Inhibitory concentration of the compounds against Bovine trypsin enzyme. | Bos taurus | 7 | ALA1130430 | single protein format | Scientific Literature | |
8. | ALA1025821 | Binding | Inhibition of bovine pancreas trypsin | Bos taurus | 7 | ALA1159252 | assay format | Scientific Literature | |
9. | ALA2399576 | ADME | Inhibition of CYP3A4/5 in human intestinal microsomes using midazolam as substrate after 4 mins | Homo sapiens | 15 | ALA2396584 | microsome format | Scientific Literature | |
10. | ALA2399577 | ADME | Inhibition of CYP2C9 in human liver microsomes using (S)-warfarin as substrate after 30 mins | Homo sapiens | 15 | ALA2396584 | microsome format | Scientific Literature | |
11. | ALA2399748 | Functional | Antiviral activity against HCV JFH-1 infected in human Huh7.5.1 cells assessed as viral core protein expression at 12.4 to 124.2 uM after 72 hrs by Western blot analysis | Hepacivirus hominis | 4 | ALA2396584 | organism-based format | Scientific Literature | |
12. | ALA2399750 | Functional | Cytotoxicity against human Huh7.5.1 cells after 72 hrs | Homo sapiens | 15 | ALA2396584 | cell-based format | Scientific Literature | |
13. | ALA3238751 | Binding | Agonist activity at human PPAR-gamma expressed in HEK293 cells at 30 ug/ml after 18 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 7 | ALA3232839 | cell-based format | Scientific Literature | |
14. | ALA3995395 | Unassigned | Antiradical activity assessed as gallic acid equivalents of Foline-Ciocalteu reagent reducing capacity at 1 mM preincubated for 5 mins followed by Na2CO3 addition measured after 90 mins | 8 | ALA3994598 | assay format | Scientific Literature | ||
15. | ALA3995396 | Functional | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins | 8 | ALA3994598 | assay format | Scientific Literature | ||
16. | ALA3995397 | Functional | Antioxidant activity assessed as trolox equivalent of ABTS radical scavenging activity at 100 uM incubated for >= 5 mins | 8 | ALA3994598 | assay format | Scientific Literature | ||
17. | ALA3995398 | Physicochemical | Partition coefficient, logP of the compound in octan-1-ol and phosphate buffer at pH 7.4 at 25 degC after 2 hrs by UV-vis spectrometer | 8 | ALA3994598 | small-molecule physicochemical format | Scientific Literature | ||
18. | ALA3995399 | Functional | Antioxidant activity against tert-butyl hydroperoxide-induced lipoperoxidation in rat liver microsomal membranes incubated for 60 mins by TBARS assay | Rattus norvegicus | 8 | ALA3994598 | cell membrane format | Scientific Literature | |
19. | ALA3995400 | ADME | Cytotoxicity against human RPE1 cells at 0.0003 to 100 uM after 48 hrs by ATPlite assay | Homo sapiens | 10 | ALA3994598 | cell-based format | Scientific Literature | |
20. | ALA3995401 | ADME | Cytotoxicity against human BJ cells at 0.0003 to 100 uM after 48 hrs by ATPlite assay | Homo sapiens | 10 | ALA3994598 | cell-based format | Scientific Literature |